DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and Cct2

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_038934664.1	Gene:	Cct2 / 299809	RGDID:	1359143	Length:	561	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	168/560 - (30%)
Similarity:	274/560 - (48%)	Gaps:	78/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDP--MGGIVMTNDGNAILR 69
            |:.:.......|.....:|.:.....||.|::::.|||:.|.|:|:..  ...:::||||..||:
  Rat    34 PVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILK 98

  Fly    70 EITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREA---- 130
            .|.|.:||||.:::::|.||:|||||||||.|||.|:|..||..:.::|||..||..:|||
  Rat    99 NIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAA 163

  Fly   131 ----LEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENG 191
                |...|.|...::....|      :.::....:.:|.:....|...|:|::||  :.|..:|
  Rat   164 REALLSSAVDHGSDEVKFWQD------LMNIAGTTLSSKLLTHHKDHFTKLAVEAV--LRLKGSG 220

  Fly   192 RLEVDIKRYAKVEKIPGGAIEESCVLKGVMINK--DVTHPKMRRLIENPRIVLLDCSLEYKKGES 254
            .||.     ..|.|..||::.:|.:.:|.:::|  .|..||.   |||.:|::.:..::..|
  Rat   221 NLEA-----IHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKR---IENAKILIANTGMDTDK--- 274

  Fly   255 QTNVEIIGEQ---DFT-RMLQIE-------EEFVQRI------C---ADIIAVKPDLVFTEKGVS 299
               ::|.|.:   |.| ::.:||       :|.|:||      |   ..:|...|:.:|...||
  Rat   275 ---IKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGV- 335

  Fly   300 DLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTF 364
             :|..:...||:.           |:|...|..|.:..:......:|: ..|.|...||::....
  Rat   336 -MAIEHADFAGVE-----------RLALVTGGEIASTFDHPELVKLGS-CKLIEEVMIGEDKLIH 387

  Fly   365 VTECKEPKACTILLRGASKDILNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQV 429
            .:.....:||||:||||::.||:|.||:|.|||.|....|.:||.|.|||..||..:..:|....
  Rat   388 FSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTMLAS 452

  Fly   430 KGP------YTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVD 488
            :.|      ..:.|.||.::|..:|.|.|.::...:..|||.|:    :|....|:|.:.|.|.|
  Rat   453 RTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHS----EGRITAGLDMKEGSIGD 513

  Fly   489 MNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVSGSKKR 528
            |.|..|.|...||.|...:|.|.|.::||:|:|:..:.::
  Rat   514 MAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	168/558 (30%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	168/554 (30%)
Cct2	XP_038934664.1	TCP1_beta	37..553	CDD:239452	167/555 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810