DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and Cct6a

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001028856.1	Gene:	Cct6a / 288620	RGDID:	1304763	Length:	531	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	152/532 - (28%)
Similarity:	283/532 - (53%)	Gaps:	32/532 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLSQNTKRESGR--KVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREIT 72
            |.:.|.|.|..|  .....||.|.:.:.||:||.|||:..:|||:...|.|.:|.|||.:|.|:.
  Rat     4 VKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQ 68

  Fly    73 VQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGH 137
            :|||.|..:.::|..||:..||||||.:::.||:|..|:.::.:.:||.:|...:..|.|..:..
  Rat    69 IQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQF 133

  Fly   138 LQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRYAK 202
            |: |:.:..:: |:..:.||.:..:.||...:.:|:..:..:|::..:...:.   .:|: ...:
  Rat   134 LE-QVKVSKEM-DRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDE---PIDL-FMVE 192

  Fly   203 VEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFT 267
            :.::...:..::.:::|::::....||.|::.:||..|:..:.||||:|.|..:.......::..
  Rat   193 IMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEERE 257

  Fly   268 RMLQIEEEFVQ-----------RICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTD 321
            ::::.|.:|::           ::|.|  :.|..:|..:||:...:...|.|.||.|:||.::.:
  Rat   258 KLVKAERKFIEDRVKKIVELKKKVCGD--SDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRN 320

  Fly   322 NLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDIL 386
            ..|:..|||...:|..::|....:| .|||.....:|:|.|||:.:|..|::.|:|::|.:|..|
  Rat   321 MERLTLACGGIALNSFDDLNPDCLG-HAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTL 384

  Fly   387 NETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLT--RKQVKG----PYTAVAHALEIIPR 445
            .:.:..::|.|...:|.:.:..:|.|.||||:|.::.|.  :..|||    ...|.|.||.|||:
  Rat   385 TQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPK 449

  Fly   446 TLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVE 510
            .||||.|.:....|..::|:| |.:|..|   |:|..:||.:......:|:...||.|...:...
  Rat   450 VLAQNSGFDLQETLVKVQAEH-SESGQLV---GVDLNTGEPMVAAEMGVWDNYCVKKQLLHSCTV 510

  Fly   511 TAILLLRIDDIV 522
            .|..:|.:|:|:
  Rat   511 IATNILLVDEIM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	152/532 (29%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	152/532 (29%)
Cct6a	NP_001028856.1	chap_CCT_zeta	3..530	CDD:274088	152/532 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820