DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and Tcp1

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_036802.1	Gene:	Tcp1 / 24818	RGDID:	3832	Length:	556	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	176/551 - (31%)
Similarity:	283/551 - (51%)	Gaps:	50/551 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSM 81
            |.:|..::.:|:.|..:||:::::.|||..:.|||:|.:|.:.:||||..||:.:.|:|||||.:
  Rat    11 RSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVL 75

  Fly    82 IEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQLSIQL 146
            .|:|..||:|||||||||:::|.|:|..|:..::|:||||.:|..||.|.::.|.::...|.|..
  Rat    76 CELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIINT 140

  Fly   147 DVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIK---RY----AKVE 204
            |...:..:.:..|..:.:|.||...|....:.:|||..|..:       ||:   ||    ..:.
  Rat   141 DELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAVKYT-------DIRGQPRYPVNSVNIL 198

  Fly   205 KIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRM 269
            |..|.:..||.::.|..:|..|....|.:.|.|.:|..||.||:..|.:....|.|...:...::
  Rat   199 KAHGRSQIESMLINGYALNCVVGSQGMLKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQI 263

  Fly   270 LQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIV 334
            .|.|.:..:.....|:|...:::.|..|:.|:...|.::||..|:||:.|.|..|||:|.||:|:
  Rat   264 RQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGASIL 328

  Fly   335 NRTEELTEKDVGTGAGLFEVKKIG-----------DEYFTFVTECKEPKACTILLRGASKDILNE 388
            :....|      .|...||...:|           |:....:...|...:.:|:||||:..:.:|
  Rat   329 STLANL------EGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDE 387

  Fly   389 TERNLQDALHVARNLVLEPRLVAGGGAVEMA--------ASQLLTRKQVKGPYTAVAHALEIIPR 445
            .||:|.|||.|.:.::....:|.||||||.|        |:.:.:|:|:  .....|.:|.:||.
  Rat   388 MERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQL--AIAEFARSLLVIPN 450

  Fly   446 TLAQNCGANTIRALTALRAKHAS---HTGDGVCAW-GIDGESGEIVDMNVKNIWEPLAVKLQTYK 506
            |||.|...::...:..|||.|..   :.......| |:|...|:..|.....::||..||:::.|
  Rat   451 TLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLK 515

  Fly   507 TAVETAILLLRIDDIV-----SGSKKRGGNE 532
            .|.|.||.:|||||::     |...|.||.|
  Rat   516 FATEAAITILRIDDLIKLHPESKDDKHGGYE 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	172/545 (32%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	171/541 (32%)
Tcp1	NP_036802.1	TCP1_alpha	9..535	CDD:239451	171/538 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810