DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and CCT5

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_036205.1	Gene:	CCT5 / 22948	HGNCID:	1618	Length:	541	Species:	Homo sapiens

Alignment Length:	538	Identity:	180/538 - (33%)
Similarity:	296/538 - (55%)	Gaps:	22/538 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QPILVLSQNTK--RESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAIL 68
            :|.|::....:  |..|.:....:|.|.||:|:.:||.|||..:.||::|..|.:.:||||..||
Human    14 RPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATIL 78

  Fly    69 REITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALED 133
            ..:.|.|..||.|:|::::||:|:|||||.|:||||.:|..||..|.:.|||..|...|.:|...
Human    79 SMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARV 143

  Fly   134 IVGHLQS-QLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDI 197
            .:.||.. ..|:.:|:||...:....|..:|:|.:........:||::||  :|:::..|.:||.
Human   144 AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAV--LTVADMERRDVDF 206

  Fly   198 KRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIG 262
            : ..|||...||.:|::.::|||:::||.:||:|.:.:|:.:|.:|.|..|..|.:::..:::..
Human   207 E-LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTS 270

  Fly   263 EQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIAR 327
            .:|:..:.:.|:|..:.:...|.....:|...:.|..|.|.|.||:..:.|:|.:...:...||.
Human   271 VEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAI 335

  Fly   328 ACGATIVNRTEELTEKDVGTGAGLFEVKKIG--DEYFTFVTECKEPKACTILLRGASKDILNETE 390
            |.|..||.|..|||.:.:|. |||.:....|  .:....:.:||..:|.||.:||.:|.|:.|.:
Human   336 ATGGRIVPRFSELTAEKLGF-AGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAK 399

  Fly   391 RNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQVKGP------YTAVAHALEIIPRTLAQ 449
            |:|.|||.|.|||:.:.|:|.||||.|::.:..::::..|.|      ..|.|.|||:||..|::
Human   400 RSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSE 464

  Fly   450 NCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAIL 514
            |.|.|.|:.:|.:||:.......   |.|||.......||..:::.|.|..|.|....|.:...:
Human   465 NSGMNPIQTMTEVRARQVKEMNP---ALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRM 526

  Fly   515 LLRIDDIVSGSKKRGGNE 532
            :|:||||    :|.|.:|
Human   527 ILKIDDI----RKPGESE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	177/531 (33%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	177/527 (34%)
CCT5	NP_036205.1	TCP1_epsilon	10..535	CDD:239455	177/531 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720