DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT3 and cct3

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_775357.1	Gene:	cct3 / 192327	ZFINID:	ZDB-GENE-020419-5	Length:	543	Species:	Danio rerio

Alignment Length:	545	Identity:	383/545 - (70%)
Similarity:	453/545 - (83%)	Gaps:	12/545 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGGQQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGN 65
            |.|  :|:||||||.|||||||||:.||.|.|.|||:|||||||:||:|||:|||||||||||||
Zfish     1 MMG--RPVLVLSQNIKRESGRKVQIGNISAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGN 63

  Fly    66 AILREITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREA 130
            ||||||.||||||||||||:|||||||||||||||:||||||:.||.||:||:||||:|.|||:|
Zfish    64 AILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEQFLEQQMHPTVVIGAYRQA 128

  Fly   131 LEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEV 195
            |:|::..|: .:|..:||.::..|..::.:.:.||.:.:||.||..||||||.||.|.||||.|:
Zfish   129 LDDMLNILK-DISTPVDVSNRDMMLKIINSAINTKALSRWSTLACNIALDAVRTVELDENGREEI 192

  Fly   196 DIKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEI 260
            |||:||||||:|||.||:||||:|||:|||||||:|||||:||||||||||||||||||||::||
Zfish   193 DIKKYAKVEKVPGGIIEDSCVLRGVMVNKDVTHPRMRRLIKNPRIVLLDCSLEYKKGESQTDIEI 257

  Fly   261 IGEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRI 325
            ..|:||.|:||:|||:||:||.|||.:||||:|||||:||||||||:||.||||||:|||||.||
Zfish   258 AREEDFARILQMEEEYVQQICEDIIRLKPDLIFTEKGISDLAQHYLMKANITAIRRIRKTDNNRI 322

  Fly   326 ARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETE 390
            ||||||.|.:||:||||.|||||.||||||||||||||||||||:|||||||||||||:||.|.|
Zfish   323 ARACGARIASRTDELTENDVGTGTGLFEVKKIGDEYFTFVTECKDPKACTILLRGASKEILAEVE 387

  Fly   391 RNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQ------VKGPYTAVAHALEIIPRTLAQ 449
            ||||||:.|.||::|:|.|:.|||||||..|..||.:.      .:.||.|||.|||::||||.|
Zfish   388 RNLQDAMQVCRNVLLDPYLLPGGGAVEMEVSHRLTERSRAMTGVEQWPYRAVAQALEVVPRTLIQ 452

  Fly   450 NCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAIL 514
            ||||:.||.||:||||   ||.:|..:||::||:|.:.||....||||||||.||||||||||||
Zfish   453 NCGASAIRVLTSLRAK---HTQEGNSSWGVNGETGTLADMEQLGIWEPLAVKAQTYKTAVETAIL 514

  Fly   515 LLRIDDIVSGSKKRGGNEPTNPAAM 539
            ||||||||||.||:|..|.|..|.|
Zfish   515 LLRIDDIVSGHKKKGDGEQTGGAPM 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	375/526 (71%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	372/522 (71%)
cct3	NP_775357.1	chap_CCT_gamma	5..528	CDD:274085	375/526 (71%)
cct3	NP_775357.1	TCP1_gamma	5..524	CDD:239453	372/522 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573304
Domainoid	1	1.000	707	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4373
Inparanoid	1	1.050	760	1.000	Inparanoid score	I532
OMA	1	1.010	-	-		QHG53994
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0004601
OrthoInspector	1	1.000	-	-		oto41446
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1488
SonicParanoid	1	1.000	-	-		X3218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800