DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and Cct3

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_033966.1	Gene:	Cct3 / 12462	MGIID:	104708	Length:	545	Species:	Mus musculus

Alignment Length:	547	Identity:	376/547 - (68%)
Similarity:	453/547 - (82%)	Gaps:	10/547 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GQQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAIL 68
            |.:|:||||||||||||||||..||.|.|.|||:|||||||::|:|||:||||||||||||||||
Mouse     3 GHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67

  Fly    69 REITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALED 133
            |||.||||||||||||:|||||||||||||||:||||||:.||.||:||:||||:|.|||.||:|
Mouse    68 REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDD 132

  Fly   134 IVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIK 198
            ::..|: ::|..:||.::..|..::.:.:.||.|.:||.||..||||||:||...||||.|:|||
Mouse   133 MISTLK-KISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIK 196

  Fly   199 RYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGE 263
            :||:|||||||.||:||||:|||||||||||:|||.|:||||||||.|||||||||||::||..|
Mouse   197 KYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITRE 261

  Fly   264 QDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARA 328
            :||||:||:|||::.::|.|||.:|||:|.||||:||||||||::|.:|||||:|||||.|||||
Mouse   262 EDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARA 326

  Fly   329 CGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERNL 393
            |||.||:|.|||.|.||||||||.|:||||||||||:|:||:|||||||||||||:||:|.||||
Mouse   327 CGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNL 391

  Fly   394 QDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQ------VKGPYTAVAHALEIIPRTLAQNCG 452
            |||:.|.||::|:|:||.||||.|||.:..||.|.      .:.||.|||.|||:|||||.||||
Mouse   392 QDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCG 456

  Fly   453 ANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLR 517
            |:|||.||:||||   ||.:....||::||:|.:|||....|||||||||||||||||||:||||
Mouse   457 ASTIRLLTSLRAK---HTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLR 518

  Fly   518 IDDIVSGSKKRGGNEPTNPAAMAQGQE 544
            |||||||.||:|.::.....|...|||
Mouse   519 IDDIVSGHKKKGDDQNRQTGAPDAGQE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	369/526 (70%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	366/522 (70%)
Cct3	NP_033966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		17/20 (85%)
		chap_CCT_gamma	6..529	CDD:274085	369/526 (70%)
		TCP1_gamma	6..525	CDD:239453	366/522 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830594
Domainoid	1	1.000	693	1.000	Domainoid score	I131
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4373
Inparanoid	1	1.050	750	1.000	Inparanoid score	I574
Isobase	1	0.950	-	0	Normalized mean entropy	S97
OMA	1	1.010	-	-		QHG53994
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004601
OrthoInspector	1	1.000	-	-		oto93461
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1488
SonicParanoid	1	1.000	-	-		X3218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740