DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and cct6a

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_958447.1	Gene:	cct6a / 116994	ZFINID:	ZDB-GENE-011018-2	Length:	531	Species:	Danio rerio

Alignment Length:	537	Identity:	155/537 - (28%)
Similarity:	279/537 - (51%)	Gaps:	42/537 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLSQNTKRESGR--KVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREIT 72
            |.:.|.|.|..|  .....||.|.:.:.||:::.|||:..:|||:...|.|.:|.|||.:|.|:.
Zfish     4 VKALNPKAEVARAHAALAVNISAARGLQDVLKSNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQ 68

  Fly    73 VQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGH 137
            :|||.|..:.::|..||:..||||||.:::.||:|..|:.::.:.:||.||...: ||.:|
Zfish    69 IQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYVSEGLHPRVIAEGF-EAAKD---- 128

  Fly   138 LQSQLSIQLDVK-----DKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDI 197
              ..|::..:||     |:..:.:|.:..:.||...:.:||..:..:|||..:.....   .:|:
Zfish   129 --KALAVLEEVKVAKEMDRETLINVARTSLRTKVHTELADLLTEAVVDAVLAIRKPNE---PIDL 188

  Fly   198 KRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIG 262
             ...::.::......::.:::|::::....||.|::.||:..|:..:.||||:|.|..:......
Zfish   189 -YMVEIMEMKHKTDSDTQLIRGLVLDHGARHPDMKKRIEDAFILTCNVSLEYEKTEVNSGFFYKS 252

  Fly   263 EQDFTRMLQIEEEFVQ-----------RICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRR 316
            ..:..::::.|.:|::           ::|||  ..|..:|..:||:...:...|.|.||.|:||
Zfish   253 ADERDKLVKAERKFIEDRVMKIIDLKNKVCAD--NKKGFVVINQKGIDPFSLDALAKEGIVALRR 315

  Fly   317 LRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGA 381
            .::.:..|:..|||...:|..|:||.:.:| .|||.....:|:|.|||:..|..|::.|:|::|.
Zfish   316 AKRRNMERLTLACGGVAMNSVEDLTPECLG-HAGLVYEYTLGEEKFTFIENCSNPRSVTLLVKGP 379

  Fly   382 SKDILNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLT--RKQVKG----PYTAVAHAL 440
            :|..|.:.:..::|.|...:|.:.:..:|||.||.|:|.:..|.  :.:|||    ...|.|.||
Zfish   380 NKHTLTQIKDAVRDGLRAVKNAIEDGSVVAGAGAFEVAVADALVKHKPKVKGRAQLGVQAFADAL 444

  Fly   441 EIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTY 505
            .:||:.||||.|.:....|..|:::. ...|..|   |:|..:||.:......:|:..:||.|..
Zfish   445 LVIPKVLAQNSGYDPQETLVKLQSEF-KEAGQLV---GVDLSTGEPMVAGEAGVWDNYSVKKQLL 505

  Fly   506 KTAVETAILLLRIDDIV 522
            .:....|..:|.:|:|:
Zfish   506 HSCTVIASNILLVDEIM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	155/537 (29%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	155/537 (29%)
cct6a	NP_958447.1	chap_CCT_zeta	3..530	CDD:274088	155/537 (29%)
cct6a	NP_958447.1	TCP1_zeta	7..526	CDD:239458	154/534 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920