DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and hspd1

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001096355.1	Gene:	hspd1 / 100124945	XenbaseID:	XB-GENE-980059	Length:	576	Species:	Xenopus tropicalis

Alignment Length:	587	Identity:	133/587 - (22%)
Similarity:	226/587 - (38%)	Gaps:	114/587 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSQNTKRESGRKVQLE------NIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILR 69
            ||.:..|:..:.|:..      .:|....:||.:...:||:....::....|...:|.||..:.:
Frog    18 LSLSLSRQYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAK 82

  Fly    70 EITV----QHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPF--LQQQIHPTVIIRAYR 128
            .|.:    ::..||.:.::|...:||.|||||:..|||..:  |.|.|  :.:..:|..|.|...
Frog    83 AIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSI--AKEGFEKISKGANPVEIRRGVM 145

  Fly   129 EALEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGK-WSDLAVKIALDAVETVTLSENGR 192
            .|::.::..|::|.......::.|::|.:  :..|.:.||| .||...::....|.||...:...
Frog   146 MAVDAVIKELKNQSKPVTTPEEIAQVATI--SANGDQEIGKIISDAMKRVGRRGVITVKDGKTLH 208

  Fly   193 LEVDI-----------------------------------KRYAKVEKI-PGGAIEESCVLKGVM 221
            .|::|                                   |:.:.|:.| |...|..:.....|:
Frog   209 DELEIIEGMKFDRGYISPYFINTAKGQKCEFQDAYLLLSEKKISSVQSIVPALEIANAHRKPLVI 273

  Fly   222 INKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQIEEEFVQRICADIIA 286
            |.:||....:..|:.|          ..|.|.....|:..|..| .|..|::         |:..
Frog   274 IAEDVDGEALSTLVLN----------RLKVGLQVVAVKAPGFGD-NRKNQLK---------DMAI 318

  Fly   287 VKPDLVFTEKG----VSDLAQHYLLKAGITAIRRLRKTDNLRIARACG--ATIVNRTEELTEKDV 345
            ....:||.|:|    :.|:..|...|.|...:.:    |:..:.:..|  |.|..|.:|:.|:..
Frog   319 SSGGVVFGEEGLTLNIEDIQPHDFGKVGEVIVTK----DDTMLLKGKGDKAQIEKRIQEIHEQLE 379

  Fly   346 GTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDI-LNETERNLQDALHVARNLVLEPRL 409
            .|.:. :|.:|:.:..      .|......::..|.:.|: :||.:..:.|||:..|..| |..:
Frog   380 STNSE-YEKEKLNERL------AKLSDGVAVIKVGGTSDVEVNEKKDRVTDALNATRAAV-EEGI 436

  Fly   410 VAGGGAVEMAASQLLTRKQVKGPYTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGV 474
            |.|||...:.....|...........|  .:|||.|||       .|.|:|.  ||:|...|..|
Frog   437 VLGGGCALLRCIPALEALNPANEDQRV--GIEIIRRTL-------KIPAMTI--AKNAGVEGSLV 490

  Fly   475 --------CAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVS---GSKKR 528
                    ...|.|....|.|::..|.|.:|..|.......|...|.||...:.:|:   ..:|.
Frog   491 VEKIIQSPVEIGYDAMHAEFVNLVEKGIIDPTKVVRTALMDAAGVASLLTTAEAVVTEIPKEEKD 555

  Fly   529 GG 530
            ||
Frog   556 GG 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	130/583 (22%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	130/579 (22%)
hspd1	NP_001096355.1	GroEL	28..548	CDD:239460	127/566 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910