DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arl6IP1 and RETREG2

DIOPT Version :9

Sequence 1:	NP_001262647.1	Gene:	Arl6IP1 / 42027	FlyBaseID:	FBgn0038453	Length:	197	Species:	Drosophila melanogaster
Sequence 2:	NP_077269.3	Gene:	RETREG2 / 79137	HGNCID:	28450	Length:	543	Species:	Homo sapiens

Alignment Length:	185	Identity:	31/185 - (16%)
Similarity:	71/185 - (38%)	Gaps:	22/185 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LEPFRTAIVGAYGVLTWEKQYYAGVVFGVISCLYLVLWYLDLSLITLLSLLGVISILLNYAFPMV 83
            |..:...:..|..:|.|||..::.|....::.|:   |.|..|.:....||.| |:|..:...:.
Human    60 LRGWEAVLAAAQRLLVWEKPLHSLVTAAALNGLF---WLLSSSSLRPFFLLSV-SLLAYFLLDLW 120

  Fly    84 SRLIFGGVNWDGDQEAKFE----------------DVCGQVCAVKGSLVVWYEYL--FNERKSTV 130
            .......|:....:|...:                ::|..:.....:..:..:.|  :..:....
Human   121 QPRFLPDVSASSPEEPHSDSEGAGSGARPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQ 185

  Fly   131 FVIVMSLGLLAMAWIGAIINNLLLMYLATLLILMWPGLQNKDIFKAITQRASKII 185
            |.:.:..|...:|.:|..:..:::.|:..|.||:||.:...::.:.:..|...::
Human   186 FCVRVCSGCAVLAVLGHYVPGIMISYIVLLSILLWPLVVYHELIQRMYTRLEPLL 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arl6IP1	NP_001262647.1	Reticulon	29..187	CDD:251305	30/175 (17%)
RETREG2	NP_077269.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..287
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..394
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..486
		LIR motif. /evidence=ECO:0000305\|PubMed:26040720	490..495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..543
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR20952
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100