DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA-l and rbm15

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_001335820.1	Gene:	rbm15 / 798517	ZFINID:	ZDB-GENE-041008-192	Length:	853	Species:	Danio rerio

Alignment Length:	642	Identity:	119/642 - (18%)
Similarity:	206/642 - (32%)	Gaps:	226/642 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NPAEKKARLGGNTQNGGG-----------VAGGGGTGGGGGGGGATGGVEFSRNRNRGGNQNENR 97
            :|.:|::|...:.::.||           ...|||:..|.....:.||   |..|...|::.:.|
Zfish     7 SPVKKRSRALDDIRDRGGSHPTSKKMGVISNSGGGSNNGNSSSKSDGG---SARRGLLGDKRDGR 68

  Fly    98 QGFQVANNSHQKQINESPKPAAGNVPAK--NNELSAGGGGQNQPNHSNKGQGNQGDQGEQGNQGP 160
            : |.                  |:|.::  ||.      |...|..|:.|:.:......:..: .
Zfish    69 E-FD------------------GHVSSRTGNNH------GYTSPVASSSGKNHASSLSLEAAR-T 107

  Fly   161 NFRGRGGGPNQPNQNANQEQSNGYPGNQ-GDNKGGQG--------------------QR------ 198
            |.||....|...|::..:.......|:| .|.:...|                    :|
Zfish   108 NSRGEARAPLPTNESEYKTLKISELGSQLSDEEIEDGLFHEFKKFGDVSVKISRVNDERIAFVNF 172

  Fly   199 ----GAGGGKHQRGN--------------RSRRSGGSGIMNS-----------------SMGGGG 228
                .|...||.||.              .:||...|.:...                 |..|.|
Zfish   173 RRPDDARAAKHARGRLVLYDRPLKIEAVYLNRRRSRSPVKEDHFSVVAGHRHLHTQRPLSPTGLG 237

  Fly   229 QRGEDFFIAQRLLDISGPTHELP-PIELPTDNKFV------------------------------ 262
            .|  |:.:.|..|....|....| |.||..:.:|.
Zfish   238 YR--DYRLQQLALGRLPPPPPPPLPRELEREREFAFYEARARPAYIAERAAPFREEDFISPEDDQ 300

  Fly   263 -GRNRLYVGNLTSDTTDDDLREMFKPYGEIGDI-FSNPEK----NFTFLRLDYYQNAEKAKRALD 321
             ....|::|||....|::|||..|:.:|.|.:: ...|.:    .:.||:.:....|.:||.::.
Zfish   301 RANRTLFLGNLDITVTENDLRRAFERFGTITEVDIKRPTRGQSSTYGFLKFENLDMAHRAKISMS 365

  Fly   322 GSLRKGRVLRVRF---APNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIV 383
            |.:.....:::.:   .|...:.|..|..:|....|.:.|:.||.|.    .:|.|...|...|.
Zfish   366 GKVVGRNPIKIGYGKATPTTRLWVGGLGPWVPLTALAREFDRFGTIR----TIDYRKGDTWAYIQ 426

  Fly   384 EFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRF 448
            ..:..::.:||..:   :.|.|                   |.||:.|.   ::|.
Zfish   427 YESLDAAQAACTHM---RGFPL-------------------GGPDRRLR---VDFA--------- 457

  Fly   449 ACLNSFEHEYGSRWKQ--------------LHDLFKSKQDSLK-RE-----LKMEEDKLEAQMEY 493
                ..||.|..::.|              :|   ::..:::: ||     |...|.:|     |
Zfish   458 ----DTEHRYQQQFLQPLPLQHYEIMAESFVH---RATPEAIRVRERTPPPLHFREREL-----Y 510

  Fly   494 ARYEQETELLRQELK----------KRELDNERMKLEWEMREKQAEEIRKREEEYMH 540
            |..|.....:|:.::          :||...|...||.|:..::|...|:..|:..|
Zfish   511 AGAEWPAPTIRERVRTPAFEPLEHLERERRREAWSLERELPGREAARKRRLMEDGRH 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	18/74 (24%)
		RRM2_p54nrb_like	339..418	CDD:240779	16/78 (21%)
		NOPS_NONA_like	409..508	CDD:240580	19/118 (16%)
		OmpH	<479..578	CDD:281871	18/77 (23%)
		DUF4472	479..559	CDD:291409	18/77 (23%)
rbm15	XP_001335820.1	RRM1_RBM15	124..201	CDD:240997	10/76 (13%)
		RRM2_RBM15	297..383	CDD:240999	18/85 (21%)
		RRM3_RBM15	386..458	CDD:241001	21/113 (19%)
		Herpes_ICP4_C	495..>685	CDD:332854	19/78 (24%)
		SPOC	684..850	CDD:311609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930