DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and SFPQ

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_005057.1	Gene:	SFPQ / 6421	HGNCID:	10774	Length:	707	Species:	Homo sapiens

Alignment Length:	671	Identity:	208/671 - (30%)
Similarity:	298/671 - (44%)	Gaps:	155/671 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GTGGGG----GGGGATGGVEFSRNRNRGGNQNENRQGFQVANNS------------HQKQINESP 115
            |.||||    ||||..||:...|:...|...|:||.........            ||:|....|
Human    10 GGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPP 74

  Fly   116 K-------------------------------------------PAAGNVPAKNNEL-------- 129
            :                                           |..|:.|..::..
Human    75 QQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTS 139

  Fly   130 -------------------------------SAG-------GGGQNQPNHSNKGQGNQGDQGEQG 156
                                           |:|       .||...|..:..|.|....|| .|
Human   140 GAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQG-PG 203

  Fly   157 NQGPNFRGRGGGPNQPNQNANQEQSNGYPGNQGDNKGGQGQRGAGGGKHQRGNRSRRSGGSGIMN 221
            ..||......||| :|..........|:|  :..::||...|  ||.:|......:...|
Human   204 PGGPKGGKMPGGP-KPGGGPGLSTPGGHP--KPPHRGGGEPR--GGRQHHPPYHQQHHQG----- 258

  Fly   222 SSMGGGGQRGEDFFIAQRLLDISGPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFK 286
            ...||.|.|.|     :::.|..|....|..:..|.:..:..|.||:||||.:|.|:|:.:.:|.
Human   259 PPPGGPGGRSE-----EKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFA 318

  Fly   287 PYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFAPN-AIVRVTNLNQFVS 350
            .|||.|::|.|..|.|.|::|:....||.||..||.:..:||.||||||.: |.:.|.||:.:||
Human   319 KYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYVS 383

  Fly   351 NELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVE 415
            ||||.::|..||||||||:.|||||:.||:||||||.|.:|......|:|..|.||.:.||.:||
Human   384 NELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIVE 448

  Fly   416 PMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKREL 480
            |:|..:|.||||:| |.:|:..::.||...||||...:||:||..|||.|.::.|.:::.:::.:
Human   449 PLEQLDDEDGLPEK-LAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNM 512

  Fly   481 KMEEDKLEAQMEYARYEQETELLRQELKKR--------ELDNERMKLEWEMREKQAEEIRKREEE 537
            |..:||||::||.|.:|.:..||||:|.:|        ||.|:.|:...||:.:|.||.|:||||
Human   513 KDAKDKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEE 577

  Fly   538 YMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILDQQE------GFGGSNSGFEHFDSPFEVF 596
            .|.|.:..    ||.||.:::|:...|.      .:|.:|      |.|..|.|        :.:
Human   578 MMIRQREM----EEQMRRQREESYSRMG------YMDPRERDMRMGGGGAMNMG--------DPY 624

  Fly   597 GNNSNNSTMAGPGGPDNSDGN 617
            |:........|.||....:.|
Human   625 GSGGQKFPPLGGGGGIGYEAN 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	339..418	CDD:240779	43/78 (55%)
		NOPS_NONA_like	409..508	CDD:240580	42/98 (43%)
		OmpH	<479..578	CDD:281871	39/112 (35%)
		DUF4472	479..559	CDD:291409	35/87 (40%)
SFPQ	NP_005057.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..273		53/278 (19%)
		3 X 3 AA repeats of R-G-G	9..27		9/16 (56%)
		RRM1_PSF	296..366	CDD:241031	32/69 (46%)
		RRM2_p54nrb_like	372..451	CDD:240779	43/78 (55%)
		NOPS_PSF	442..538	CDD:240583	41/96 (43%)
		PTZ00121	<499..>599	CDD:173412	37/103 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..707		19/85 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154203
Domainoid	1	1.000	74	1.000	Domainoid score	I9124
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2670
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm8550
orthoMCL	1	0.900	-	-		OOG6_107408
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790