DRSC/TRiP Functional Genomics Resources

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Protein Alignment nonA-l and PSPC1

DIOPT Version :9

Sequence 1:NP_001262646.1 Gene:nonA-l / 42026 FlyBaseID:FBgn0015520 Length:630 Species:Drosophila melanogaster
Sequence 2:NP_001035879.1 Gene:PSPC1 / 55269 HGNCID:20320 Length:523 Species:Homo sapiens


Alignment Length:391 Identity:152/391 - (38%)
Similarity:233/391 - (59%) Gaps:27/391 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 GPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDY 309
            |.|.::.....|.:..:..|.||:||||.:|.|::|.:.:|:.|||..::|.|.::.|.|:||:.
Human    62 GFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLES 126

  Fly   310 YQNAEKAKRALDGSLRKGRVLRVRFAPN-AIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDD 373
            ...||.||..|||::.|.|.||:|||.: |.:.|.||:..||||||.|:|..|||:|:||:.|||
Human   127 RTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDD 191

  Fly   374 RGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEF 438
            ||:.||:|.||||.|..|...|..|.:..|.||.:.||.:|||||..:|.||||:| |.:|:.::
Human   192 RGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEK-LMQKTQQY 255

  Fly   439 RHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELL 503
            ..||...||||...:||.||.||||.|.::.|.:::.:.|.::..::||||:||.||:|.:..|:
Human   256 HKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLM 320

  Fly   504 RQELKKR--------ELDNERMKLEWEMREKQAEEIRKREEEYM-HRYQNQLLRHEEDMRARQQE 559
            ||:|.:|        ||.|:.::...:::.:..||.|:||||.: ||.|.:|.|.:|..:....|
Human   321 RQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYME 385

  Fly   560 NDLLMQAKKLNM-------ILDQQEGFGGSNSGFEHFDSPFEVFGNNSNN-STMAGPG-GPDNSD 615
            |    :.:::.|       .::..:.|..:.:|.:   .|..:.|.|.|| :|:.||. ||..:.
Human   386 N----REQEMRMGDMGPRGAINMGDAFSPAPAGNQ---GPPPMMGMNMNNRATIPGPPMGPGPAM 443

  Fly   616 G 616
            |
Human   444 G 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonA-lNP_001262646.1 RRM1_p54nrb_like 264..334 CDD:240778 31/69 (45%)
RRM2_p54nrb_like 339..418 CDD:240779 41/78 (53%)
NOPS_NONA_like 409..508 CDD:240580 44/98 (45%)
OmpH <479..578 CDD:281871 33/114 (29%)
DUF4472 479..559 CDD:291409 30/88 (34%)
PSPC1NP_001035879.1 RRM1_PSP1 81..151 CDD:241030 31/69 (45%)
Sufficient for paraspeckles localization 125..358 102/233 (44%)
RRM2_PSP1 157..236 CDD:241033 41/78 (53%)
NOPS_PSPC1 227..320 CDD:240584 41/93 (44%)
Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269|PubMed:16148043 231..358 49/127 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 74 1.000 Domainoid score I9124
eggNOG 1 0.900 - - E1_KOG0115
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 303 1.000 Inparanoid score I2670
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1274880at2759
OrthoFinder 1 1.000 - - FOG0001632
OrthoInspector 1 1.000 - - mtm8550
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23189
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4077
SonicParanoid 1 1.000 - - X1036
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.960

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