DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA-l and NONO

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001138880.1	Gene:	NONO / 4841	HGNCID:	7871	Length:	471	Species:	Homo sapiens

Alignment Length:	339	Identity:	143/339 - (42%)
Similarity:	212/339 - (62%)	Gaps:	20/339 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 GPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDY 309
            |.|.:|.....|.:..|..|:||:||||..|.|::::|::|:.||:.|::|.:.:|.|.|:||:.
Human    54 GLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLET 118

  Fly   310 YQNAEKAKRALDGSLRKGRVLRVRFA-PNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDD 373
            ...||.||..||....:|:.|||||| .:|.:.|.||.|:||||||.::|.:||.:||||:.|||
Human   119 RTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDD 183

  Fly   374 RGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEF 438
            ||:.:|:|||||:.|.:|...|..|:|..|.||...||..||||:..:|.:|||:| |..|:.:|
Human   184 RGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEK-LVIKNQQF 247

  Fly   439 RHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELL 503
            ..||...||||...|||:||..|||.|.::.|.:||.:.|.:|...:|||.:||.||:|.:..|:
Human   248 HKEREQPPRFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLM 312

  Fly   504 RQELKKRELDNERMKLEWEMREKQAEEIRKREEEYMHRYQNQLLRHEEDMRARQQENDLLMQAKK 568
            ||:|.:|:.:..||:      |...:|::||::..: |.:.:..|.||:||.:|:|
Human   313 RQDLMRRQEELRRME------ELHNQEVQKRKQLEL-RQEEERRRREEEMRRQQEE--------- 361

  Fly   569 LNMILDQQEGFGGS 582
              |:..|||||.|:
Human   362 --MMRRQQEGFKGT 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	30/69 (43%)
		RRM2_p54nrb_like	339..418	CDD:240779	41/78 (53%)
		NOPS_NONA_like	409..508	CDD:240580	45/98 (46%)
		OmpH	<479..578	CDD:281871	31/98 (32%)
		DUF4472	479..559	CDD:291409	27/79 (34%)
NONO	NP_001138880.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		DBHS	54..373		142/337 (42%)
		RRM1_p54nrb	73..143	CDD:410001	30/69 (43%)
		RRM_SF	149..228	CDD:418427	41/78 (53%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	42/92 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154197
Domainoid	1	1.000	74	1.000	Domainoid score	I9124
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2670
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm8550
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890