DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and spen

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	142/826 - (17%)
Similarity:	220/826 - (26%)	Gaps:	396/826 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SSPLPQRQQRGNSTNKNLGKPTPPKLNAASD------GNPAEKKA------RLGGNTQNGGGV-- 62
            :|.|..:.|..|||:......:|..::|::.      |..:|:..      |.|..:..|||:
  Fly    79 TSRLVTQYQANNSTSLANSNSSPSSVSASASVFATAAGGSSERSRNRDRPYRNGSASVQGGGINS 143

  Fly    63 -----------AGGG-----GTGGGGGGGGATGGV-EFSRNRNRGGNQNENRQGFQVAN------ 104
                       |||.     |||.||..|...||| :...:|:...|.::|.|..:||.
  Fly   144 SNTTTTTAACTAGGSGSGAIGTGTGGLVGSGPGGVPQALGDRSSTQNIHQNHQSARVAPPQSWYE 208

  Fly   105 ----------------------------------NSHQKQ-----------INESPKPAAGNVP- 123
                                              |.|..|           ...||...||:.|
  Fly   209 AATAATTAQLKSSGGSGNAGASAAVGFTMSSSPINHHPHQHPHLQNPQHPHYTSSPVVGAGSCPS 273

  Fly   124 ---------------AKNNELSAGGG----------GQNQPNHSN------KGQGNQGDQGEQ-G 156
                           |.:..::..|.          .:|...||:      ||.|..|..||: |
  Fly   274 AAQGQPQIQSQSQTTAVHRSVAYAGSAADDLLNTATSRNMLLHSSKLNKLLKGAGATGSGGERSG 338

  Fly   157 NQGPNFRGRGGGPNQPNQNANQEQSNGYPGNQGDN-------------KGGQGQRGAGGG----- 203
            ::.|   ||.||.. |....:...:|.:..|..:|             .|..|..|.|.|
  Fly   339 SESP---GRAGGAT-PLTTTSTITNNSFSSNSLNNTITTATPTMPTIASGAAGSVGLGSGAEAGV 399

  Fly   204 -----------------------------------------------KHQR-------------- 207
                                                           .|.|
  Fly   400 CSNSGTASGDILNVAAVLAAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSS 464

  Fly   208 ----------------GN------RSRR-----------SGGSG----IMNSSMGGG-------- 227
                            ||      ||.|           |..||    :.::.:|||
  Fly   465 SHSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSS 529

  Fly   228 -------------------------------------------------------------GQRG 231
                                                                         ||..
  Fly   530 SSSSSSGSSCLTANPVVHSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNS 594

  Fly   232 EDFFI--------AQRLLDISGPTH-------------------ELPPIELPTDNKFVGRNR-LY 268
            |.:.:        .::.|::|...|                   |..|.|...|.......| |:
  Fly   595 ERYALVCFKKPDDVEKALEVSHDKHFFGCKIEVEPYQGYDVEDNEFRPYEAELDEYHPKSTRTLF 659

  Fly   269 VGNLTSDTTDDDLREMFKPYGEI--GDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLR 331
            :|||..|.|..:||..|:.:|||  .||.......:.|.:.....:..||.|.:||.......::
  Fly   660 IGNLEKDITAGELRSHFEAFGEIIEIDIKKQGLNAYAFCQYSDIVSVVKAMRKMDGEHLGSNRIK 724

  Fly   332 VRFA---PNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASA 393
            :.|.   |...|.:..:::.||...|...|..||.:.:..|   ||.:..  .:|.:.:..:|.|
  Fly   725 LGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSI---DRNRQL--ALVLYDQVQNAQA 784

  Fly   394 CLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEY 458
            .::                         |..|   ..|.:|.|:.                  ::
  Fly   785 AVK-------------------------DMRG---TILRRKKLQV------------------DF 803

  Fly   459 GSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLR 504
            .||  :..|.|..||:      |.::....:...::|||.....|:
  Fly   804 ASR--ECQDAFYDKQE------KQQQQSSGSNPRFSRYESSASSLQ 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	21/72 (29%)
		RRM2_p54nrb_like	339..418	CDD:240779	13/78 (17%)
		NOPS_NONA_like	409..508	CDD:240580	16/96 (17%)
		OmpH	<479..578	CDD:281871	5/26 (19%)
		DUF4472	479..559	CDD:291409	5/26 (19%)
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	6/72 (8%)
		RRM3_SHARP	654..726	CDD:240796	21/71 (30%)
		RRM4_SHARP	727..803	CDD:240797	20/126 (16%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459922
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23189
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030