DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and nono

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_963873.1	Gene:	nono / 321994	ZFINID:	ZDB-GENE-030131-713	Length:	441	Species:	Danio rerio

Alignment Length:	485	Identity:	167/485 - (34%)
Similarity:	254/485 - (52%)	Gaps:	83/485 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 QGNQGDQGEQGNQGPNFRGRGGGPNQPN-QNANQEQSNGYPGNQGDNKGGQGQRGAGGGKH-QRG 208
            |||:|.:.||.|.||.       ..||| |...|.:..|...|               |:| ..|
Zfish     2 QGNRGPRSEQQNHGPQ-------RQQPNPQQEQQRKPTGADSN---------------GQHTDAG 44

  Fly   209 NRSRRSGGSGIMNSSMGGGGQRGEDFFIAQRLLDISGPTHELPPIELPTDNKFVGRNRLYVGNLT 273
            .:|..:.|.                             |.:|...:.|.:..:..|:||:||||.
Zfish    45 EQSSPNAGF-----------------------------TIDLQNFKKPGEKTYTQRSRLFVGNLP 80

  Fly   274 SDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFAPN- 337
            :.||::|:.::|..||:..:||.|.::.|.|:||:....|:.||..||.::.:||.:|||||.:
Zfish    81 AGTTEEDVEKLFSKYGKASEIFINKDRGFGFIRLETKTLADIAKAELDDTIFRGRQIRVRFATHG 145

  Fly   338 AIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACLRLCNEKC 402
            |.:.|.||.||||||||.::|.:|||||||::.|||||:.||:||||||.|.||...|..|.:..
Zfish   146 AALTVKNLPQFVSNELLEEAFSMFGPIERAIVIVDDRGRPTGKGIVEFANKPSARKALDRCGDGA 210

  Fly   403 FFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHD 467
            |.|||..||..:||||..::.:|||::.:||..: :..||...||||...|||:||..|||.|.:
Zfish   211 FLLTAFPRPVTIEPMEQLDEEEGLPERLINKNPV-YHKEREQPPRFAQPGSFEYEYAMRWKALME 274

  Fly   468 LFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKRELDNERMKLEWEMREKQAEEIR 532
            :.|.:.:.:.|.:|..::|||.::|.||:|.:..|:||:|.:|:.:..||:      |..::|::
Zfish   275 MEKQQYEQVDRNIKEAKEKLETELEAARHEHQVMLMRQDLLRRQEELRRME------EAHSQEVQ 333

  Fly   533 KREEEYMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILDQQEGFGGSNSGFEHFDSPFEVF- 596
            ||::..: |.:.:..|.||::||..:|            ::.:|:|.||:.|  |..|....:.
Zfish   334 KRKQMEL-RQEEERRRREEELRAHSEE------------LMRRQQGQGGNFS--EKRDPDMRMHM 383

  Fly   597 ---GNNSNNSTMAGPG---GPDNSDGNQHG 620
               |...|.:.|.|..   |..|...|:.|
Zfish   384 GGQGMGMNRNPMGGNASNTGSTNLTSNEQG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	29/69 (42%)
		RRM2_p54nrb_like	339..418	CDD:240779	45/78 (58%)
		NOPS_NONA_like	409..508	CDD:240580	39/98 (40%)
		OmpH	<479..578	CDD:281871	27/98 (28%)
		DUF4472	479..559	CDD:291409	25/79 (32%)
nono	NP_963873.1	RRM_SF	71..141	CDD:302621	29/69 (42%)
		RRM2_p54nrb	147..226	CDD:241035	45/78 (58%)
		NOPS_p54nrb	217..310	CDD:240582	36/93 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589400
Domainoid	1	1.000	77	1.000	Domainoid score	I8758
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3072
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm6571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890