DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and Rbm15b

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_038938548.1	Gene:	Rbm15b / 315988	RGDID:	1305937	Length:	887	Species:	Rattus norvegicus

Alignment Length:	673	Identity:	131/673 - (19%)
Similarity:	222/673 - (32%)	Gaps:	221/673 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKNSLNSSPLPQRQQRGNSTNKNLGKPTPPKLNAASDGNPAEKKARLGGNTQN-----------G 59
            ::|..:|||    ..||:|::..  :|...:..|.:.|..|..||  .|.|::           |
  Rat     3 RQNERDSSP----SGRGSSSSAK--RPREREREAEAGGRRAAHKA--SGGTKHPVPARARDKPRG 59

  Fly    60 GGVAGG----------------GGTGGGGGGGGATGGVEFSRNRNRGGNQNENRQGFQVANNSHQ 108
            .|..||                |.:.|..||||.||  :.|.:...||             .|.:
  Rat    60 SGGGGGHRDGRAAGDANHRASSGRSSGAPGGGGRTG--KASGDPGAGG-------------ASPR 109

  Fly   109 KQINESPKPAAGNVPAKNNELSAGGGGQNQPN-----------------------HSNKGQG--- 147
            ......|.|..|..|       ||.|....|.                       |..|..|
  Rat   110 ASPLPPPPPPPGAEP-------AGPGTTAAPEYKTLLISSLSPALPAEHLEDRLFHQFKRFGEIS 167

  Fly   148 -NQGDQGEQGNQG-PNFRG------------------------------RGGGPNQPNQNANQEQ 180
             ......|.|... .|||.                              ||||.::.:.:::...
  Rat   168 LRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYLRGGGSSRRSSSSSAAA 232

  Fly   181 SNGYPG--NQGDNKGGQGQRGAGGGKHQ----------RGNRSRRSGGSGIMN----SSMGGGGQ 229
            |...||  ...|..|.....|....|.:          |..|:|.:..:..::    :::|...:
  Rat   233 STPPPGPPTPADPLGYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRE 297

  Fly   230 RGEDFFIAQRLLDISGPTHELPPI----ELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGE 290
            |..|::   .|.|..|..:....:    .:|.|::...|| |::|||....::.:||..|:.||.
  Rat   298 RALDYY---GLYDDRGRPYSYQAVCEEDLMPEDDQRATRN-LFIGNLDHSVSEVELRRAFEKYGI 358

  Fly   291 IGD-IFSNPEKN----FTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFA---PNAIVRVTNLNQ 347
            |.: :...|.:.    :.||:......|.:||.|:.|.:.....:::.:.   |...:.|..|..
  Rat   359 IEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGP 423

  Fly   348 FVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSA-SACLRLCNEKCFFLTASLRP 411
            ..|...|.:.|:.||.| |.:    |..|......:::....:| :||.::   :.|.|
  Rat   424 NTSLAALAREFDRFGSI-RTI----DHVKGDSFAYIQYESLDAAQAACAKM---RGFPL------ 474

  Fly   412 CLVEPMEVNNDNDGLPDKTLN---KKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQ 473
                         |.||:.|.   .|:.|.|:.:...|         ......::.|.|.: ::.
  Rat   475 -------------GGPDRRLRVDFAKAEETRYPQQYQP---------SPLPVHYELLTDGY-TRH 516

  Fly   474 DSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKRELDNERMKLE--WEMREKQAEEIRKREE 536
            .:|..:|:: .|:....:.|:                  |.:|..||  |....|.::.
  Rat   517 RNLDADLRV-RDRTPPHLLYS------------------DRDRTFLEGDWTSLSKSSDR------ 556

  Fly   537 EYMHRYQNQLLRHEEDMRARQQE 559
                  :|.|..:...:|:|..|
  Rat   557 ------RNSLEGYSRSVRSRSGE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	20/74 (27%)
		RRM2_p54nrb_like	339..418	CDD:240779	16/79 (20%)
		NOPS_NONA_like	409..508	CDD:240580	14/101 (14%)
		OmpH	<479..578	CDD:281871	14/83 (17%)
		DUF4472	479..559	CDD:291409	13/81 (16%)
Rbm15b	XP_038938548.1	RRM1_RBM15B	134..215	CDD:409970	8/80 (10%)
		RRM2_RBM15B	325..409	CDD:409972	22/84 (26%)
		RRM3_RBM15B	412..487	CDD:409974	21/101 (21%)
		SF-CC1	568..>704	CDD:273721	3/6 (50%)
		SPOC	711..884	CDD:400205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840