DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA-l and Pspc1

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001020843.1	Gene:	Pspc1 / 305910	RGDID:	1310122	Length:	522	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	160/434 - (36%)
Similarity:	244/434 - (56%)	Gaps:	49/434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 MNSSMGGGGQRGEDFFIAQRLLDISG-------PTHELPPIEL-----------PTDNKFVGRNR 266
            :.|:.|    ..|....|...|.::|       |:.|.|..|:           |.:..:..|.|
  Rat    22 LESAAG----ESEPVAAAAMALTLAGEQPPPPAPSEEHPDEEMGFTIDIKSFLKPGEKTYTQRCR 82

  Fly   267 LYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLR 331
            |:||||.:|.|::|.:.:|:.|||..::|.|.::.|.|:||:....||.||..|||::.|.|.||
  Rat    83 LFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLR 147

  Fly   332 VRFAPN-AIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACL 395
            :|||.: |.:.|.||:..||||||.|:|..|||:|:||:.|||||:.||:|.||||.|..|...|
  Rat   148 IRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKAL 212

  Fly   396 RLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGS 460
            ..|.:..|.||.:.||.:|||||..:|.||||:| |.:|:.::..||...||||...:||.||.|
  Rat   213 ERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEK-LMQKTQQYHKEREQPPRFAQPGTFEFEYAS 276

  Fly   461 RWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKR--------ELDNERM 517
            |||.|.::.|.:::.:.|.::..::||||:||.||:|.:..|:||:|.:|        ||.|:.:
  Rat   277 RWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQEL 341

  Fly   518 KLEWEMREKQAEEIRKREEEYM-HRYQNQLLRHEEDMRARQQENDLLMQAKKLNM-------ILD 574
            :...:::.:..||.|:||||.: ||.|.:|.|.:|..:....||    :.:::.|       .::
  Rat   342 QKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMEN----REQEMRMGDMGPRGAIN 402

  Fly   575 QQEGFGGSNSGFEHFDSPFEVFGNNSNN-STMAGPG-GPDNSDG 616
            ..:.|..:.:|.:   .|..:.|.|.|| .|:.||. ||..:.|
  Rat   403 MGDAFSPAPAGTQ---GPPPMMGMNMNNRGTIPGPPMGPGPAMG 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	31/69 (45%)
		RRM2_p54nrb_like	339..418	CDD:240779	41/78 (53%)
		NOPS_NONA_like	409..508	CDD:240580	44/98 (45%)
		OmpH	<479..578	CDD:281871	33/114 (29%)
		DUF4472	479..559	CDD:291409	30/88 (34%)
Pspc1	NP_001020843.1	RRM1_PSP1	80..150	CDD:241030	31/69 (45%)
		Sufficient for paraspeckles localization. /evidence=ECO:0000250	124..357		102/233 (44%)
		RRM2_PSP1	156..235	CDD:241033	41/78 (53%)
		NOPS_PSPC1	226..319	CDD:240584	41/93 (44%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000250	230..357		49/127 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8891
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm9026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930