DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and Sfpq

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001020442.1	Gene:	Sfpq / 252855	RGDID:	727923	Length:	699	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	209/668 - (31%)
Similarity:	298/668 - (44%)	Gaps:	159/668 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GTGGGG----GGGGATGGVEFSRNRNRGGNQNENRQGFQVANNS----------HQKQ------- 110
            |.||||    ||||..||:...|:...|...|:||.........          ||:|
  Rat    10 GGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGGPKPPLPPPPPHQQQQQPPPQQ 74

  Fly   111 ------------------------------------------INESPKPAAGNVPAKNNELSAGG 133
                                                      ::.:|.||....||  |..:.|.
  Rat    75 PPPQQPPPHQQPPPHQPPHQQPPPPPQESKPVVPQGPGSAPGVSTAPPPAVSAPPA--NPPTTGA 137

  Fly   134 --------------------------------------GGQNQPNHSNKGQG---NQGDQGEQGN 157
                                                  ||...|.....|.|   ..|..|.:|.
  Rat   138 PPGPGPTPTPPPAVPSTAPGPPPPSTPSSGVSTTPPQTGGPPPPPAGGAGPGPKQGPGPGGPKGG 202

  Fly   158 QGPNFRGRGGGPNQPNQNANQEQSNGYPGN--QGDNKGGQGQRGAGGGKHQRGNRSRRSGGSGIM 220
            :.|.....||||..           |.||.  :..::||...|  ||.:|......:...|
  Rat   203 KMPGGPKPGGGPGM-----------GAPGGHPKPPHRGGGEPR--GGRQHHAPYHQQHHQG---- 250

  Fly   221 NSSMGGGGQRGEDFFIAQRLLDISGPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMF 285
             ...||.|.|.|     :::.|..|....|..:..|.:..:..|.||:||||.:|.|:|:.:.:|
  Rat   251 -PPPGGPGPRTE-----EKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLF 309

  Fly   286 KPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFAPN-AIVRVTNLNQFV 349
            ..|||.|::|.|..|.|.|::|:....||.||..||.:..:||.||||||.: |.:.|.||:.:|
  Rat   310 AKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYV 374

  Fly   350 SNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLV 414
            |||||.::|..||||||||:.|||||:.||:||||||.|.:|......|:|..|.||.:.||.:|
  Rat   375 SNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIV 439

  Fly   415 EPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRE 479
            ||:|..:|.||||:| |.:|:..::.||...||||...:||:||..|||.|.::.|.:::.:::.
  Rat   440 EPLEQLDDEDGLPEK-LAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKN 503

  Fly   480 LKMEEDKLEAQMEYARYEQETELLRQELKKR--------ELDNERMKLEWEMREKQAEEIRKREE 536
            :|..:||||::||.|.:|.:..||||:|.:|        ||.::.|:...||:.:|.||.|:|||
  Rat   504 MKDAKDKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHSQEMQKRKEMQLRQEEERRRREE 568

  Fly   537 EYMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILDQQE-----GFGGSNSGFEHFDS---PF 593
            |.|.|.:..    ||.||.:::|:...|.      .:|.:|     |.||:.:..:.:.|   .|
  Rat   569 EMMIRQREM----EEQMRRQREESYSRMG------YMDPRERDMRMGGGGTMNMGDPYGSGGQKF 623

  Fly   594 EVFGNNSNNSTMAGPGGP 611
            ...|........|.||.|
  Rat   624 PPLGGGGGIGYEANPGVP 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	339..418	CDD:240779	43/78 (55%)
		NOPS_NONA_like	409..508	CDD:240580	42/98 (43%)
		OmpH	<479..578	CDD:281871	38/111 (34%)
		DUF4472	479..559	CDD:291409	34/87 (39%)
Sfpq	NP_001020442.1	RRM1_PSF	288..358	CDD:410000	32/69 (46%)
		RRM2_PSF	364..443	CDD:410003	43/78 (55%)
		NOPS_PSF	434..530	CDD:240583	41/96 (43%)
		PRK12704	478..>586	CDD:237177	43/111 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm9026
orthoMCL	1	0.900	-	-		OOG6_107408
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970