DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and Rbm15

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001039272.1	Gene:	Rbm15 / 229700	MGIID:	2443205	Length:	962	Species:	Mus musculus

Alignment Length:	823	Identity:	151/823 - (18%)
Similarity:	251/823 - (30%)	Gaps:	286/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLNSSPLPQRQQRGNSTN----------------KNLGKPTPPKLNAASDGNPAEKKARLGGNTQ 57
            |....|||:|..|....:                .:|.:|:..|   ..:.:|.:.|...||...
Mouse     3 SAGREPLPRRSPRWRRASPLCETSAGWRVSQLRRDDLRRPSTMK---GKERSPVKPKRSRGGEDS 64

  Fly    58 NGGG-----VAGGGGTGGGGGG----GGATGGVEFSRNRNRGGNQNENRQGFQVANNSHQKQINE 113
            :..|     :.|.||:.|...|    ||:...:...::.:|||::.     ::....|...:::.
Mouse    65 SSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKSSSRGGSRE-----YETGGGSSSSRLHS 124

  Fly   114 SPKPAAGNVPAKNNELSAGGGGQNQPNHSNKGQGNQGDQGEQGNQGPNFRGRGGGPNQPNQNANQ 178
            ...|:..|        |:|||   :...|::|.|     ||..:.|......|||.....:....
Mouse   125 YSSPSTKN--------SSGGG---ESRSSSRGGG-----GESRSSGAASSAPGGGDGVEYKTLKI 173

  Fly   179 EQSNGYPGNQGDNKG---------------------GQGQ-----------RGAGGGKHQRG--- 208
            .:......::....|                     |.|.           ..|...||.||
Mouse   174 SELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLV 238

  Fly   209 ---------------NRSRR-------SGGSGIMNSSM--------GGGGQRG----------ED 233
                           .|||.       :..|.::.:|:        ||||||.          .|
Mouse   239 LYDRPLKIEAVYVSRRRSRSPLDKDAYAPSSSVVGTSVGSHRHAPGGGGGQRSLSPGGAALGYRD 303

  Fly   234 FFIAQRLLDISGPTHELPPIELP------TDNKFVGRNR-------------------------- 266
            :.:.|..|....|.   ||..||      .|..|..|.|
Mouse   304 YRLQQLALGRLPPP---PPPPLPRELERERDYPFYDRVRPAYSLEPRVGAGAGAAPFREVDEISP 365

  Fly   267 ---------LYVGNLTSDTTDDDLREMFKPYGEIGDI-FSNPEKNFT----FLRLDYYQNAEKAK 317
                     |::|||....|::|||..|..:|.|.:: ...|.:..|    ||:.:....:.:||
Mouse   366 EDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAK 430

  Fly   318 RALDGSLRKGRVLRVRF---APNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTG 379
            .|:.|.:.....:::.:   .|...:.|..|..:|....|.:.|:.||.| |.:    |..|...
Mouse   431 LAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTI-RTI----DYRKGDS 490

  Fly   380 EGIVEFAKKSSASAC---------------LRL--CNEKCFFLTASLRPCLVEPMEVNNDNDG-- 425
            ...:::....:|.|.               ||:  .:.:..:....|:|..:...|:..|..|
Mouse   491 WAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHR 555

  Fly   426 LPDKTLNKKS----LEFR-------------------HERSVGPRFACLNSFEHEYGSRWKQLHD 467
            .||...:.:.    |.:|                   .|||.....:.:.::|
Mouse   556 APDPLRSARDRTPPLLYRDRDRDLYTDSDWVPPPPPVRERSARAATSAVTAYE------------ 608

  Fly   468 LFKSKQDSLKRE---LKMEEDKLEAQMEYARYEQETELLRQELKKRELDNERMKLEWEMREKQAE 529
                ..|||.|.   ..::.|:.:..:..:|.:.....|.:|...|.||          |..::|
Mouse   609 ----PLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLD----------RSPESE 659

  Fly   530 EIRKRE------------EEYMHRYQNQ--------LLRHEEDMRARQQENDLLMQAKKLNMILD 574
            ..||:.            .....||.:.        ||.....:|.|:...:.....|:     |
Mouse   660 RPRKQRHCTPSPDRSPELSSNRDRYNSDNDRSSRLLLLERSSPVRDRRGSLEKSQSDKR-----D 719

  Fly   575 QQEGFGGSNSGFEHFDSPFEVFGNNSNNSTMAGPGGPDNSDGN 617
            ::..............:|.|  |.|....       .|.||||
Mouse   720 RKNSASAERDRKHRTAAPTE--GKNPLKK-------EDRSDGN 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	21/109 (19%)
		RRM2_p54nrb_like	339..418	CDD:240779	17/95 (18%)
		NOPS_NONA_like	409..508	CDD:240580	21/126 (17%)
		OmpH	<479..578	CDD:281871	19/121 (16%)
		DUF4472	479..559	CDD:291409	17/102 (17%)
Rbm15	NP_001039272.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..167		40/187 (21%)
		RRM1_RBM15	168..250	CDD:240997	8/81 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..297		9/39 (23%)
		RRM2_RBM15	366..452	CDD:240999	19/85 (22%)
		RRM3_RBM15	455..527	CDD:241001	15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..779		41/241 (17%)
		RRM	623..>751	CDD:330708	24/151 (16%)
		SPOC	781..955	CDD:311609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930