DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and nono-1

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_498295.3	Gene:	nono-1 / 175844	WormBaseID:	WBGene00017778	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	159/492 - (32%)
Similarity:	237/492 - (48%)	Gaps:	99/492 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 GQNQPNHSNKGQGNQGDQGE-QGNQGPNFRGRGGGPNQPNQNANQEQSNGYPGNQG--------- 189
            |..:.|..:.|:.:.....: :.::.|....|||...:.|.|.......|..||:|
Worm     3 GARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEKRGNSNNAARSGGGGGGNRGGAERGIAPA 67

  Fly   190 ----DNKGGQGQRGAGGGKHQRGNRSRRSGGSGIMNSSMGGGGQRGEDFFIAQRLLDISGPTHEL 250
                ||.||. :.|.|||         ||||.|   :|..|..      |...:|:|
Worm    68 QQPYDNNGGH-RSGGGGG---------RSGGGG---TSFNGAA------FTESQLMD-------- 105

  Fly   251 PPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEK 315
               |:| ..||.||.||:||||.::..:.:|:|:|.|:|:|.:.:.: .|.|.|||||...:||.
Worm   106 ---EVP-KKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLS-GKGFAFLRLDTRAHAES 165

  Fly   316 AKRALDGSLRKGRVLRVRFAPN-AIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTG 379
            ||.|:||.:..||.:|||||.: |.:||..|:..||||:|:.:|..||.:||||..||::|:.||
Worm   166 AKEAIDGRIIHGRQVRVRFAVHGAAIRVKELSPTVSNEMLYHAFSHFGDVERAVHIVDEKGRPTG 230

  Fly   380 EGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSV 444
            ||||||.:|.:.:..:....:|.|.||||.:|.:.|.:|..:::|||.::.: .::.....||.:
Worm   231 EGIVEFERKPNCNEAMAAIRDKVFLLTASPKPLICEVLEPRDEDDGLAERMI-PRTPGLSKEREL 294

  Fly   445 GPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKK 509
            ||||...||||:.||.:||:|:.:.:.::..|..||:....:||:.||.| |:.
Worm   295 GPRFPTPNSFEYVYGMKWKELYVVEQKRRAQLDEELRESRRRLESDMELA-YQD----------- 347

  Fly   510 RELDNERMKLEWEMREKQAEEIRKREEEYMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILD 574
                                            ||.|:||  ||::.||||.:.|..|::     :
Worm   348 --------------------------------YQAQMLR--EDLQRRQQELERLEAARR-----E 373

  Fly   575 QQEGFGGSNSGFEHFDSPFEVFGNNSNNSTMAGPGGP 611
            :..|.||...|......|.....|....|...|||||
Worm   374 RMRGLGGPPPGMPGGVPPQAQPFNPHGGSMFGGPGGP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	31/69 (45%)
		RRM2_p54nrb_like	339..418	CDD:240779	35/78 (45%)
		NOPS_NONA_like	409..508	CDD:240580	30/98 (31%)
		OmpH	<479..578	CDD:281871	21/98 (21%)
		DUF4472	479..559	CDD:291409	17/79 (22%)
nono-1	NP_498295.3	RRM1_p54nrb_like	115..184	CDD:240778	31/69 (45%)
		RRM2_p54nrb_like	190..269	CDD:240779	35/78 (45%)
		eNOPS_SF	260..349	CDD:240579	30/133 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163389
Domainoid	1	1.000	66	1.000	Domainoid score	I6530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1965
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		otm14306
orthoMCL	1	0.900	-	-		OOG6_107408
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930