DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and Rbm15b

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_780611.3	Gene:	Rbm15b / 109095	MGIID:	1923598	Length:	887	Species:	Mus musculus

Alignment Length:	751	Identity:	148/751 - (19%)
Similarity:	248/751 - (33%)	Gaps:	225/751 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKNSLNSSPLPQRQQRGNSTNKNLGKPTPPKLNAASDGNPAEKKARLGGNTQN------------ 58
            :::..:|||    ..||:|::..  :|...:..|.:.|..|..||  .|.|::
Mouse     3 RQSERDSSP----SGRGSSSSAK--RPREREREAEAGGRRAAHKA--SGGTKHPVPARARDKPRG 59

  Fly    59 ---GGG------------VAGGGGTGGGGGGGGATGGVEFSRNRNRGGNQNENRQGFQVANNSHQ 108
               |||            .|.||.:.|..||||.||  :.|.:...||             .|.:
Mouse    60 SGGGGGHRDGRAAGDANHRASGGRSSGAPGGGGRTG--KASGDPGAGG-------------ASPR 109

  Fly   109 KQINESPKPAAGNVPAKNNELSAGGGGQNQPN-----------------------HSNKGQG--- 147
            ......|.|..|..|       ||.|....|.                       |..|..|
Mouse   110 ASPLPPPPPPPGAEP-------AGPGSTAAPEYKTLLISSLSPALPAEHLEDRLFHQFKRFGEIS 167

  Fly   148 -NQGDQGEQGNQG-PNFRG------------------------------RGGGPNQPNQNANQEQ 180
             ......|.|... .|||.                              ||||.::.:.:::...
Mouse   168 LRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYLRGGGSSRRSSSSSAAA 232

  Fly   181 SNGYPG--NQGDNKGGQGQRGAGGGKHQ----------RGNRSRRSGGSGIMN----SSMGGGGQ 229
            |...||  ...|..|.....|....|.:          |..|:|.:..:..::    :::|...:
Mouse   233 STPPPGPPAPADPLGYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRE 297

  Fly   230 RGEDFFIAQRLLDISGPTHELPPI----ELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGE 290
            |..|::   .|.|..|..:....:    .:|.|::...|| |::|||....::.:||..|:.||.
Mouse   298 RALDYY---GLYDDRGRPYGYQAVCEEDLMPEDDQRATRN-LFIGNLDHSVSEVELRRAFEKYGI 358

  Fly   291 IGD-IFSNPEKN----FTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFA---PNAIVRVTNLNQ 347
            |.: :...|.:.    :.||:......|.:||.|:.|.:.....:::.:.   |...:.|..|..
Mouse   359 IEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGP 423

  Fly   348 FVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSA-SACLRLCNEKCFFLTASLRP 411
            ..|...|.:.|:.||.| |.:    |..|......:::....:| :||.::   :.|.|
Mouse   424 NTSLAALAREFDRFGSI-RTI----DHVKGDSFAYIQYESLDAAQAACAKM---RGFPL------ 474

  Fly   412 CLVEPMEVNNDNDGLPDKTLN---KKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQ 473
                         |.||:.|.   .|:.|.|:.:...|         ......::.|.|.: ::.
Mouse   475 -------------GGPDRRLRVDFAKAEETRYPQQYQP---------SPLPVHYELLTDGY-TRH 516

  Fly   474 DSLKRELKMEEDKLEAQMEYARYEQE------TELLRQELKKRELDNERMKLEWEMRE------- 525
            .:|..:|:: .|:....:.|:..::.      |.|.:...::..|:.....:.....|
Mouse   517 RNLDADLRV-RDRTPPHLLYSDRDRTFLEGDWTSLSKSSDRRNSLEGYSRSVRSRSGERWGGDGD 580

  Fly   526 ----KQAEEIRKREEEYMHRYQNQLLRHEEDMRAR----QQENDLLMQAKKLNMILDQQEGF--G 580
                |..||.|||......|.:.....:||..|.:    |.|.......::........||.  .
Mouse   581 RSIAKPWEERRKRRSLSSDRGRTTHSPYEERSRTKGGGQQSERGSDRTPERSRKENHSSEGTKES 645

  Fly   581 GSNS------GFE-------HFDSPFEVFGNNSNNS 603
            ||||      |.|       |.::|....|..:..|
Mouse   646 GSNSLSNSRHGAEERSHHHHHHEAPDSSHGKKTRES 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	20/74 (27%)
		RRM2_p54nrb_like	339..418	CDD:240779	16/79 (20%)
		NOPS_NONA_like	409..508	CDD:240580	16/107 (15%)
		OmpH	<479..578	CDD:281871	19/119 (16%)
		DUF4472	479..559	CDD:291409	18/100 (18%)
Rbm15b	NP_780611.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132		38/158 (24%)
		RRM1_RBM15B	134..215	CDD:240998	8/80 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..249		9/33 (27%)
		RRM2_RBM15B	325..409	CDD:241000	22/84 (26%)
		RRM3_RBM15B	412..487	CDD:241002	21/101 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..703		27/133 (20%)
		SR-25	568..>712	CDD:287471	25/114 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	590..594		2/3 (67%)
		Interaction with Epstein-Barr virus BMLF1. /evidence=ECO:0000250	719..887
		SPOC	719..854	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840