DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA-l and sfpq

DIOPT Version :9

Sequence 1:	NP_001262646.1	Gene:	nonA-l / 42026	FlyBaseID:	FBgn0015520	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001121427.1	Gene:	sfpq / 100158518	XenbaseID:	XB-GENE-5968416	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	661	Identity:	210/661 - (31%)
Similarity:	314/661 - (47%)	Gaps:	139/661 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QNGGGVAGGGG-----TGGGGGGGG-----ATGGVEFSR----NRNRGGNQNENRQGFQVANNSH 107
            :|.||  ||||     .|.||.|||     .:|.::.:|    |:.:|..|.:.:|..|.|
Frog     7 RNRGG--GGGGMSIYRRGNGGRGGGMPNYRGSGYMDSNRGPHQNQQQGPPQQKQQQDKQPA---- 65

  Fly   108 QKQINESPKPAAGNVPAKNNELSAGGGGQNQPNHSNKGQGNQGD----QGEQGNQGPNFRGRGGG 168
            |:|..::|.|.  ..||:            ||..:.|.|.:|..    |..|....|:.:.:.|.
Frog    66 QQQQKQTPAPE--QKPAQ------------QPQAATKPQDSQAPQPPAQSPQSKPAPSPQQKPGT 116

  Fly   169 PNQPNQNANQ----------------------EQSNGYPGNQGDNKGGQGQRGAGGGKHQRGNRS 211
            ..|..|:..|                      :|....|.|...::...||...  ..||:..:.
Frog   117 TPQQQQSQPQSSPAKPVPQTPPQQLQKPPQQPQQQKPAPPNNASSQAKPGQPPV--HHHQQQQQR 179

  Fly   212 RRSGGSGIMNSSMGGGGQR--------------------GEDFFIAQRLLDISGPTH----ELPP 252
            .|.|        |...||:                    .|:...|.   |:||.:.    .|..
Frog   180 SRPG--------MNQVGQKRPHQSRFQSQPPPHAMESDAAEEKSSAD---DVSGWSDGVRATLSL 233

  Fly   253 IELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAK 317
            ::.|.:..:..|.||:||||.:|..||:.:::|:.|||.|::|.|..|.|.|::|:....||.||
Frog   234 LKRPGEKTYTQRCRLFVGNLPTDINDDEFKKLFEKYGEPGEVFINKSKGFGFIKLETRALAEIAK 298

  Fly   318 RALDGSLRKGRVLRVRFAP-NAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEG 381
            ..||....:||.||||||. :|.:.|.||:.|||||||.::|..|||:||||:.|||||:.||:|
Frog   299 AELDDLPMRGRQLRVRFATHSAALSVRNLSPFVSNELLEEAFSQFGPVERAVVIVDDRGRSTGKG 363

  Fly   382 IVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGP 446
            |||||.|.:|...|..|.:..|.||.:..|.:|||:|..:|.||||:|...|..| ::.||.|.|
Frog   364 IVEFAAKPAARKALERCTDGVFLLTTTPMPVIVEPLEQFDDEDGLPEKLAQKNHL-YQKEREVPP 427

  Fly   447 RFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKR- 510
            |||...:||.||..|||.|.::.|.::..:::.:|..::|||::||.|.:|.:..||||:|.:|
Frog   428 RFAQHGTFEFEYSQRWKSLDEMEKQQRAQVEKNMKEAKEKLESEMEDAYHEHQANLLRQDLMRRQ 492

  Fly   511 -------ELDNERMKLEWEMREKQAEEIRKREEEYMHRYQNQLLRHEEDMRARQQ---------- 558
                   ||.|:.|:...||:.:|.||.|:||||.:.|.:..    ||.||.:::
Frog   493 EELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMLLRQREM----EEQMRRQREEGYRMSYMDP 553

  Fly   559 -ENDLLMQAKKLNM------ILDQQEGFGGSNSGFEHFDSP--------FEVFGNNSNNST-MAG 607
             |.|:.|.|.:::|      ...:....||:..|:|  :||        ..:.|.:..|.. :.|
Frog   554 RERDMRMGASQMSMADPYGAASQKYPPLGGAGMGYE--NSPGVAQATISSSIMGGDMRNERFVQG 616

  Fly   608 PGGPDNSDGNQ 618
            ..|..|:..::
Frog   617 NAGTPNAQASR 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA-l	NP_001262646.1	RRM1_p54nrb_like	264..334	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	339..418	CDD:240779	42/78 (54%)
		NOPS_NONA_like	409..508	CDD:240580	41/98 (42%)
		OmpH	<479..578	CDD:281871	38/123 (31%)
		DUF4472	479..559	CDD:291409	33/98 (34%)
sfpq	NP_001121427.1	RRM1_PSF	245..315	CDD:241031	32/69 (46%)
		RRM2_p54nrb_like	321..400	CDD:240779	42/78 (54%)
		NOPS_PSF	391..487	CDD:240583	40/96 (42%)
		OmpH	<438..>511	CDD:281871	25/72 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8956
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2885
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm9442
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060