Protein Alignment Fas1 and STAB2

DIOPT Version :10

• Sequence 1: NP_001097814.1
• Gene: Fas1 / 42025
• FlyBaseID: FBgn0285925
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_060034.9
• Gene: STAB2 / 55576
• HGNCID: 18629
• Length: 2551
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 77/372 - (20%)
• Similarity: 138/372 - (37%)
• Gaps: 99/372 - (26%)

  Fly   297 VGVVLAEIVKANIP---------VSNGVVHLIHRPLMIID-----TTVTQFLQE-NAE-----NG 341
            ||..:.:|.|::.|         |:.|....|.:...:.|     ..:.:.|:| |.|     .|
Human   318 VGCSMTDICKSDNPCHRNANCTTVAPGRTECICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQG 382

  Fly   342 ALRKFYEVIMDNGGAVLDDINSLTEVTILAPSNEAWNSSNINNVLRDRNKMRQILNMHIIKDRLN 406
            .|..|.. ::|.  |....::.|...|:|.|:::.....|:|.:|.|....:..:.:|||..::|
Human   383 RLTSFIS-LLDK--AYAWPLSKLGPFTVLLPTDKGLKGFNVNELLVDNKAAQYFVKLHIIAGQMN 444

  Fly   407 VDKIRQKNANLIAQVPTVNNNTFLYFNVRGEGSDTV---------ITVEGGGVNATVIQADVAQT 462
            ::.:               |||.:::.:.|:..:..         :.:.||.....:||.|:..:
Human   445 IEYM---------------NNTDMFYTLTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIAS 494

  Fly   463 NGYVHIIDHVLGVPYTTVLGKLESDPMMSDTYKMGKFSHFNDQLNNTQ-----------RRFTYF 516
            ||.:||:|..:.....|.....|...|   |....::|.|...|..|.           ..:|.|
Human   495 NGLLHILDRAMDKLEPTFESNNEQTIM---TMLQPRYSKFRSLLEETNLGHALDEDGVGGPYTIF 556

  Fly   517 VPRDKGWQKTE---LDY---PSAHKKLF------MADFSY----------HSKS----------- 548
            ||.::.....:   |||   |...:||.      :..|:.          |.:|
Human   557 VPNNEALNNMKDGTLDYLLSPEGSRKLLELVRYHIVPFTQLEVATLISTPHIRSMANQLIQFNTT 621

  Fly   549 ----ILERHLAISDKEYTMKDLVKFSQESGSVILPTFRDSLSIRVEE 591
                ||...:|:.:.|.|.|: .:....:|.:|.|:....|..|.:|
Human   622 DNGQILANDVAMEEIEITAKN-GRIYTLTGVLIPPSIVPILPHRCDE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fas1	NP_001097814.1	Fasciclin	49..159	CDD:396845
		FAS1	215..324	CDD:214719	8/35 (23%)
		FAS1	368..476	CDD:214719	25/116 (22%)
		Fasciclin	488..627	CDD:396845	31/152 (20%)
STAB2	NP_060034.9	EGF_3	246..275	CDD:463759
		EGF_3	326..361	CDD:463759	6/34 (18%)
		Fasciclin	382..505	CDD:396845	31/140 (22%)
		Fasciclin	526..654	CDD:396845	24/128 (19%)
		EGF_3	837..865	CDD:463759
		EGF_3	876..908	CDD:463759
		EGF_3	920..951	CDD:463759
		EGF_3	957..993	CDD:463759
		Fasciclin	1009..1129	CDD:396845
		Fasciclin	1148..1265	CDD:396845
		EGF_3	1437..1469	CDD:463759
		EGF_3	1475..1511	CDD:463759
		EGF_3	1517..1553	CDD:463759
		EGF_3	1559..1595	CDD:463759
		Fasciclin	1617..1726	CDD:396845
		Fasciclin	1752..1882	CDD:396845
		EGF_3	2086..2121	CDD:463759
		EGF_3	2127..2164	CDD:463759
		Link_domain_TSG_6_like	2198..2290	CDD:239592
		FAS1	2356..2449	CDD:214719
		Interaction with TMSB4X. /evidence=ECO:0000269|PubMed:18519035	2504..2514
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2512..2551