DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14893 and FAR2

DIOPT Version :9

Sequence 1:	NP_650568.2	Gene:	CG14893 / 42023	FlyBaseID:	FBgn0038451	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_011519049.1	Gene:	FAR2 / 55711	HGNCID:	25531	Length:	535	Species:	Homo sapiens

Alignment Length:	513	Identity:	180/513 - (35%)
Similarity:	277/513 - (53%)	Gaps:	56/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IQGFYKDKVVFLTGATGFLGKVIIEKLLRTT-EVKRIYAMMRPKRGKDIQERLAIWQKDPLFEVL 79
            |..||..|.:.:||||||||||::|||.||: ::|.||.::|||.|:.:|:|:.......|||.:
Human    24 IAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKV 88

  Fly    80 LKAKPDALKRIFVIAGDCLDPDLGINRSDRKLLVSEVHIVIHGAATVRFNEPLHVALAINTRGTR 144
            .:..|:..::|..|..|....|..|::.|.:.|:|..:|:.|.||||||::.|..|:.:|...||
Human    89 KEVCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTATR 153

  Fly   145 LMLQLAKEMLQLEAYLHISTAFSNCVIFRIEEKFYPEHLTC--DANSVLAMSELLSEQMMDKLAP 207
            .:|.:|.:|.:|||::|||||:|||.:..|:|..||    |  :...::...|.|.:.::|::.|
Human   154 QLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYP----CPVEPKKIIDSLEWLDDAIIDEITP 214

  Fly   208 TLVGNFPNTYTYTKALAEDVVLREFGDLPLSIFRPSVIIATHEEPVSGWIDNLYGPIAHIYGVSH 272
            .|:.::||.|||||||.|.||.:|..:|.::|.|||::.||.:||..||:||:.||...|.....
Human   215 KLIRDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGK 279

  Fly   273 GVLRLTTYDKDGYASLVPVDYCANAALASIWQTS--KDKS----------------QRNAISQPA 319
            |.||.........|.::|||...|..||..|.|:  :.||                .:..:...|
Human   280 GFLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNPCNWHKMGVQVLA 344

  Fly   320 IYTLAPSEKNLLL-NTDFIKHSLIHRNDFPLTKMIWYPFVHNISNPRIFPLAAFFYHTLPGYFYD 383
            .:...|.|:.... |.:|..:|        .|...|    :.:|            |..|...||
Human   345 TFEKIPFERPFRRPNANFTSNS--------FTSQYW----NAVS------------HRAPAIIYD 385

  Fly   384 LALRLSGRKPRLVKLYRSIHANIAVLEHFMNNSWHFETKSTDRLRVMMSPEDRRLYNFDMETLDW 448
            ..|||:|||||:.||...:...:::||:|:|.||.:.|.:|:.|...:||||:|::|||:..|:|
Human   386 CYLRLTGRKPRMTKLMNRLLRTVSMLEYFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNW 450

  Fly   449 KEYFRKALFGMRLYLTKEPPTQESLEQGRRLFYRLKILHYSFVTLLCVIAGFLLWTLV 506
            .||....:.|::.||.||  ....:.:.::...||:.:||.|.|.|.:||    |.|:
Human   451 LEYIENYVLGVKKYLLKE--DMAGIPKAKQRLKRLRNIHYLFNTALFLIA----WRLL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14893	NP_650568.2	PLN02996	19..452	CDD:215538	162/454 (36%)
		FAR-N_SDR_e	23..339	CDD:187547	122/337 (36%)
		Sterile	375..465	CDD:281068	38/89 (43%)
FAR2	XP_011519049.1	PLN02996	22..467	CDD:215538	167/470 (36%)
		FAR-N_SDR_e	31..335	CDD:187547	117/307 (38%)
		Sterile	377..467	CDD:281068	38/89 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157505
Domainoid	1	1.000	93	1.000	Domainoid score	I7542
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800