DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14893 and Far2

DIOPT Version :9

Sequence 1:	NP_650568.2	Gene:	CG14893 / 42023	FlyBaseID:	FBgn0038451	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006237759.1	Gene:	Far2 / 500368	RGDID:	1565966	Length:	515	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	190/518 - (36%)
Similarity:	281/518 - (54%)	Gaps:	66/518 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IQGFYKDKVVFLTGATGFLGKVIIEKLLRTT-EVKRIYAMMRPKRGKDIQERLAIWQKDPLFEVL 79
            |..||.:|.:.:||||||||||::|||.||: .:|.||.::|||.|:.:|||:.......|||.:
  Rat     4 IAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQILNSKLFERV 68

  Fly    80 LKAKPDALKRIFVIAGDCLDPDLGINRSDRKLLVSEVHIVIHGAATVRFNEPLHVALAINTRGTR 144
            .:..|:..::|..|:.|....|..|::.|.:.|:|..:||.|.||||||:..|..|:.:|...|:
  Rat    69 KEVCPNVHEKIRPISADLNQRDFAISKEDMQELLSCTNIVFHCAATVRFDAHLREAVQLNVTATQ 133

  Fly   145 LMLQLAKEMLQLEAYLHISTAFSNCVIFRIEEKFYPEHLTC--DANSVLAMSELLSEQMMDKLAP 207
            .:|.:|.||.:|||::|||||||||.:..|:|..||    |  :...::...|.|.:.:::::.|
  Rat   134 QLLLMASEMPKLEAFIHISTAFSNCNLSHIDEVIYP----CPVEPRKIIDSMEWLDDSIIEEITP 194

  Fly   208 TLVGNFPNTYTYTKALAEDVVLREFGDLPLSIFRPSVIIATHEEPVSGWIDNLYGPIAHIYGVSH 272
            .|:|:.||||||||||.|.||.:|.|:|.::|.|||::.||.:||..||:|||.||...|.....
  Rat   195 KLIGDRPNTYTYTKALGEVVVQQESGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGK 259

  Fly   273 GVLRLTTYDKDGYASLVPVDYCANAALASIWQTSKDKSQRNAISQPAIYTLAPS---EKNLLL-- 332
            |.||.........|.|:|||...|..:|..|.|:..:.:...|.......|.|.   |..|.:
  Rat   260 GFLRSIKATPMAVADLIPVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYEMGLQVLA 324

  Fly   333 --------------NTDFIKHSLIHRNDFPLTKMIWYPFVHNISNPRIFPLAAFFYHTLPGYFYD 383
                          |.||.      .|:|  |...|    :.:|            |..|...||
  Rat   325 TVEKIPFESAFRRPNADFT------TNNF--TTQYW----NTVS------------HWAPAIIYD 365

  Fly   384 LALRLSGRKPRLVKLYRSIHANIAVLEHFMNNSWHFETKSTDRLRVMMSPEDRRLYNFDMETLDW 448
            ..|||:|||||::||...:...|::||:|:|:||.:.|.:|:.|...:||||:|::|||:..|:|
  Rat   366 FYLRLTGRKPRMLKLMNRLLKTISMLEYFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNW 430

  Fly   449 KEYFRKALFGMRLYLTKE-----PPTQESLEQGRRLFYRLKILHYSFVTLLCVIAGFLLWTLV 506
            .||....:.|::.||.||     |..::.|:       ||:.:||.|.|.|.:|    :|.|:
  Rat   431 LEYIENYVLGVKKYLLKEDLAGIPKAKQHLK-------RLRNIHYLFNTALFLI----IWRLL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14893	NP_650568.2	PLN02996	19..452	CDD:215538	171/454 (38%)
		FAR-N_SDR_e	23..339	CDD:187547	129/337 (38%)
		Sterile	375..465	CDD:281068	39/89 (44%)
Far2	XP_006237759.1	FAR-N_SDR_e	11..318	CDD:187547	124/310 (40%)
Far2	XP_006237759.1	Sterile	357..447	CDD:397244	39/89 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351505
Domainoid	1	1.000	94	1.000	Domainoid score	I7266
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850