DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14893 and CG30427

DIOPT Version :9

Sequence 1:	NP_650568.2	Gene:	CG14893 / 42023	FlyBaseID:	FBgn0038451	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001246512.1	Gene:	CG30427 / 37986	FlyBaseID:	FBgn0043792	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	161/518 - (31%)
Similarity:	267/518 - (51%)	Gaps:	58/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IQGFYKDKVVFLTGATGFLGKVIIEKLLRTT-EVKRIYAMMRPKRGKDIQERLAIWQKDPLFEVL 79
            :|.:||||.:|:|||:||:|||::||||.:. .:|.:..:.||||||..:.||....|.|:|:.:
  Fly     8 VQEYYKDKTIFITGASGFMGKVLLEKLLYSCHSLKEVIIICRPKRGKAPETRLEEMFKLPIFQRI 72

  Fly    80 LKAKPDALKRIFVIAGDCLDPDLGINRSDRKLLVSEVHIVIHGAATVRFNEPLHVALAINTRGTR 144
            ...:|:.|||:.:..||.....||::....|.:....:||.|.|||::....|..|:.:|..|||
  Fly    73 KDERPEMLKRVTIYQGDVTFDQLGLSGESLKHVTENTNIVFHMAATLKLEGNLRDAIDMNLLGTR 137

  Fly   145 LMLQLAKEMLQLEAYLHISTAFSNCVIFRIEEKFY-----PEHLTCDANSVLAMSELLSEQMMDK 204
            ..|.:||||.||||::|:||||.||....:.||.|     ||.|       :.::|.:..:.:|.
  Fly   138 RALNVAKEMKQLEAFIHLSTAFCNCDQDVMYEKVYEFPHKPEDL-------MRLAEWMDVKTLDA 195

  Fly   205 LAPTLVGNFPNTYTYTKALAEDVVLREFGDLPLSIFRPSVIIATHEEPVSGWIDNLYGPIAHIYG 269
            :.|.|:...||||||:|.|||.:|...:..:|:.|.|||::.....||:.||:||:.||...:.|
  Fly   196 ITPDLLKPHPNTYTYSKRLAELLVRDHYESMPVIIARPSIVTPAVAEPLPGWVDNMNGPTGVLIG 260

  Fly   270 VSHGVLRLTTYDKDGYASLVPVDYCANAALASIWQTSKDKSQRNAISQPAIYTLAPSEKN----- 329
            ...||:|....:.:..:.::|||...|..:...:..|  .:::..:..| :|.|...:..
  Fly   261 AGKGVIRSMICNGELKSEVIPVDIAINGLILLPYHNS--LAEKRPLQIP-VYNLTVDDAKKRTWK 322

  Fly   330 --LLLNTDF-IKHSLIHRNDFPLTKMIWYPFVHNISNPRIFPLAAFFYHT--------LPGYFYD 383
              :.:..|. ||        :|....:|||..:..|:.        ||||        ||.|..|
  Fly   323 WIMDVGRDLGIK--------YPFEVGLWYPDGNMTSSK--------FYHTICTILFMWLPAYLID 371

  Fly   384 LALRLSGRKPRLVKLYRSIHANIAVLEHFMNNSWHFETKSTDRLRVMMSPEDRRLYNFDMETLDW 448
            ..|.:.|::..::::...|...:.||:.|...||.|::...:::...:...|||::..:.:.:|.
  Fly   372 FLLLIFGQRRFMIRVQTKIAVGLEVLQFFTTRSWDFKSTHFEQIYKELGSTDRRIFKINTDDVDD 436

  Fly   449 KEYFRKALFGMRLYLTKEPPTQESLEQGRRLFYRLKILHYSFVTLLC---VIAGFLLWTLVRL 508
            .||.:.::.|.|.|:.|||.|  ||.:.|   .:|:.::  .:..:|   :|:|.|.|...:|
  Fly   437 YEYMKVSILGGRQYVMKEPLT--SLPKSR---IQLRFMY--VLDRICKTMIISGLLYWVSQKL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14893	NP_650568.2	PLN02996	19..452	CDD:215538	142/454 (31%)
		FAR-N_SDR_e	23..339	CDD:187547	111/329 (34%)
		Sterile	375..465	CDD:281068	24/97 (25%)
CG30427	NP_001246512.1	FAR-N_SDR_e	15..321	CDD:187547	109/315 (35%)
CG30427	NP_001246512.1	Sterile	364..453	CDD:281068	22/88 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466759
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	1	0.950	-	0	Normalized mean entropy	S3821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	11	10.850