DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14893 and CG4020

DIOPT Version :9

Sequence 1:	NP_650568.2	Gene:	CG14893 / 42023	FlyBaseID:	FBgn0038451	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001259264.1	Gene:	CG4020 / 31522	FlyBaseID:	FBgn0029821	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	175/500 - (35%)
Similarity:	274/500 - (54%)	Gaps:	28/500 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YKDKVVFLTGATGFLGKVIIEKLLRT-TEVKRIYAMMRPKRGKDIQERLAIWQKDPLFEVLLKAK 83
            ::|:.:|:|||:||:||.:||||||: .::.|||.:||||:|..|:|||.:..:..|:|.|.:.:
  Fly     7 FEDQEIFVTGASGFVGKALIEKLLRSCPKLGRIYVLMRPKKGHTIEERLQLQWESRLYERLRREQ 71

  Fly    84 PDALKRIFVIAGDCLDPDLGINRSDRKLLVSEVHIVIHGAATVRFNEPLHVALAINTRGTRLMLQ 148
            |:|..::..||||.....|||..:|.:.| ..|:||.|.||:|||::.|..|:.:|||||..:::
  Fly    72 PNARSKLVAIAGDVEQLGLGIGSADLERL-RNVNIVYHSAASVRFDDALSTAILLNTRGTHELVK 135

  Fly   149 LAKEMLQLEAYLHISTAFSNCVIFRIEEKFYPEHLTCDANSVLAMSELLSEQMMDKLAPTLVGNF 213
            ||.|..:|:|::|:||.:||..:..:||:.||.  ..|..:.:.::|....:::| :.....|||
  Fly   136 LALEWPKLKAFVHVSTTYSNPGVLEVEERVYPP--LADWRTTIKLAETYDAEILD-IFNLKYGNF 197

  Fly   214 -PNTYTYTKALAEDVVLREFGD-LPLSIFRPSVIIATHEEPVSGWIDNLYGPIAHIYGVSHGVLR 276
             |||||:||:|||.|| .|:.| ||:.|||||::::|.||||.||.||..||...:.....|:||
  Fly   198 QPNTYTFTKSLAEQVV-NEYRDRLPIFIFRPSIVVSTIEEPVPGWADNFNGPTGLLVACGVGILR 261

  Fly   277 LTTYDKDGYASLVPVDYCANAALASIWQ-----TSKDKSQRNAISQPAIYTLAPSEKNLLLNTDF 336
            ....|.:..|..||.|..|...:.|:::     .|:.|.....:...|...::|.....:::
  Fly   262 SQNCDPNIVADFVPADIVARTLITSVYKFMGESKSRAKDSDLYVVNCATANISPITMGEVID--- 323

  Fly   337 IKHSLIHRNDFPLTKMIWYPFVHNISNPRIFPLAAFFYHTLPGYFYDLALRLSGRKPRLVKLYRS 401
            |..:.|.:|  |..|.:|.|.....:.|.:..:.....|.|.....|..|||...||.|:||.|.
  Fly   324 IGKTFIRKN--PFEKTLWLPGGGMTTCPVLHFVRFCTMHLLMAIVVDTLLRLYNEKPFLMKLQRR 386

  Fly   402 IHANIAVLEHFMNNSWHFETKSTDRLRVMMSPEDRRLYNF-DMETLDWKEYFRKALFGMRLYLTK 465
            |.|..:.|:.|....|||:..:...|..::...:...:.| ....:::.|:|:..:.|.:.:|.|
  Fly   387 IFAAFSALQVFAMTEWHFQNDNFRALHDVVPANEVSNFGFMQHANINYTEFFQHGIRGAKEFLLK 451

  Fly   466 EPPTQESLEQGR-RLFYRLKIL----HYSFVTLLCVIAGFL--LW 503
            |.|...|..:.| ::||.|..|    .|||  ||.:|..||  ||
  Fly   452 ESPESSSAARFRVKIFYVLDFLCRGIVYSF--LLRLIFRFLVRLW 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14893	NP_650568.2	PLN02996	19..452	CDD:215538	153/440 (35%)
		FAR-N_SDR_e	23..339	CDD:187547	123/323 (38%)
		Sterile	375..465	CDD:281068	25/90 (28%)
CG4020	NP_001259264.1	FAR-N_SDR_e	12..333	CDD:187547	125/330 (38%)
CG4020	NP_001259264.1	FAR_C	359..450	CDD:176924	24/90 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466786
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.900