DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14893 and Far1

DIOPT Version :9

Sequence 1:	NP_650568.2	Gene:	CG14893 / 42023	FlyBaseID:	FBgn0038451	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001011933.1	Gene:	Far1 / 293173	RGDID:	1306647	Length:	515	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	171/499 - (34%)
Similarity:	271/499 - (54%)	Gaps:	23/499 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IQGFYKDKVVFLTGATGFLGKVIIEKLLRT-TEVKRIYAMMRPKRGKDIQERLAIWQKDPLFEVL 79
            |..:|:.|.:.|||||||||||::|||||: .:|..:|.::|.|.|:..|||:.......||:.|
  Rat     4 IPEYYEGKNILLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEILSGKLFDRL 68

  Fly    80 LKAKPDALKRIFVIAGDCLDPDLGINRSDRKLLVSEVHIVIHGAATVRFNEPLHVALAINTRGTR 144
            ....||..::|..|..:...|.|.::..|:::::...:::.|.||||||||.|..|:.:|...||
  Rat    69 RDENPDFRQKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATR 133

  Fly   145 LMLQLAKEMLQLEAYLHISTAFSNCVIFRIEEKFYPEHLTCDANSVLAMSELLSEQMMDKLAPTL 209
            .::.||::|..||.::|:|||::.|....|:|..||..:  |...::...|.:.:.:::.:.|.|
  Rat   134 QLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPV--DPKKLIDSLEWMDDGLVNDITPKL 196

  Fly   210 VGNFPNTYTYTKALAEDVVLREFGDLPLSIFRPSVIIATHEEPVSGWIDNLYGPIAHIYGVSHGV 274
            :|:.||||.|||||||.||.:|...|.::|.|||::.|:.:||..|||||..||.........|:
  Rat   197 IGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGI 261

  Fly   275 LRLTTYDKDGYASLVPVDYCANAALASIWQTSKDKSQRNAISQPAIYTLAPSEKNLL---LNTDF 336
            ||......:..|.|||||...|.:||:.|.:..:: .||.:    :|.......|..   ...|:
  Rat   262 LRTMRASNNALADLVPVDVVVNTSLAAAWYSGVNR-PRNIM----VYNCTTGSTNPFHWGEVGDY 321

  Fly   337 IKHSLIHRNDFPLTKMIWYPFVHNISNPRIFPLAAFFYHTLPGYFYDLALRLSGRKPRLVKLYRS 401
            :.||.   ...||.::..:|:|...||..:........||:|....||||||:|:||.::|....
  Rat   322 LNHSF---KTNPLNQVFRHPYVKFYSNNLMLHYWKGVKHTVPALLLDLALRLTGQKPWMMKTITR 383

  Fly   402 IHANIAVLEHFMNNSWHFETKSTDRLRVMMSPEDRRLYNFDMETLDWKEYFRKALFGMRLYLTKE 466
            :|..:..||:|.:|||.:.|.:.:.|...::|||::.:|.|:..|.|.||......|.:.|:..|
  Rat   384 LHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNE 448

  Fly   467 PPTQESLEQGRRLFYRLKILHYSFVTLLCVIAGFLLWTLVRLFI 510
              ....|...|:...:|:.:.|.|.|:|.:    |:|   |:||
  Rat   449 --EMSGLPAARKHLNKLRNIRYGFNTILVI----LIW---RIFI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14893	NP_650568.2	PLN02996	19..452	CDD:215538	154/436 (35%)
		FAR-N_SDR_e	23..339	CDD:187547	115/319 (36%)
		Sterile	375..465	CDD:281068	33/89 (37%)
Far1	NP_001011933.1	PLN02996	2..446	CDD:215538	158/451 (35%)
		FAR-N_SDR_e	11..330	CDD:187547	117/328 (36%)
		Sterile	371..447	CDD:281068	24/75 (32%)
		Necessary and sufficient for PEX19-mediated localization into peroxisome membrane. /evidence=ECO:0000250\|UniProtKB:Q8WVX9	451..507		12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351488
Domainoid	1	1.000	94	1.000	Domainoid score	I7266
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750