DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17560 and FarO

DIOPT Version :9

Sequence 1:	NP_650567.1	Gene:	CG17560 / 42022	FlyBaseID:	FBgn0038450	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_652021.1	Gene:	FarO / 45707	FlyBaseID:	FBgn0023550	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	147/537 - (27%)
Similarity:	255/537 - (47%)	Gaps:	93/537 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSEIQGFFKNKTVFLTGGTGFLGKVIIEKLLRTTEVNRIYSLIRPKRGVPIEDRITTWAKDPVF 65
            :..|::.||::..:|:|||:|.:||.::|||||:..|.|||.|:||::.:..|.|:....:..||
  Fly     5 LSGEMEEFFEDSEIFVTGGSGVVGKALVEKLLRSCNVRRIYVLLRPRKQLTAEQRLVRLRQATVF 69

  Fly    66 EVLLRTKPDALQRVCPIAGDCLDPDLGISQSDQRILTAEVQIVIHGAATVRFDEALHISLAINVR 130
            .||...||:.|.::..:.||...|.|||..|..:.:.. |.:|.|.||||||||.|..::.:||.
  Fly    70 HVLAVQKPEELDKIVAVPGDVSLPGLGIDPSMMQRMKG-VSLVYHCAATVRFDEPLREAVRLNVG 133

  Fly   131 ATRLMLQLAKQMTQLVSFVHVSTAYSNCVVHDIAERFYPEHLN---CSSDKILAVGELVSNKLLD 192
            .|...|:.|:.:.||.:|:||||.|||..:..:..::|...::   |    :..:.::..:.:|:
  Fly   134 GTLEALKFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLC----LRMIDDVADDGMLN 194

  Fly   193 AMEPSLVGSFPNTYTYTKALAEDVILREAGNLPLSIFRPAIIMSTYKEPLVGWVDNLFGPLALCF 257
            |:...|:..||||||:||.|||.::......||:.::||:|::...::|..|:..:|.|.:.|..
  Fly   195 ALTRKLIMGFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFA 259

  Fly   258 GGARGIMRVTTVDPSAKISLVPADYCVNVALACAWRTAEISVQNGKVTTPPIYAFAPSENNLMSY 322
            ....||::...:....::.:.|.|..:. ::.|..:......:.|.....|:
  Fly   260 LVGAGILKTVYLGKDIRLDITPQDIGIK-SMLCYTKMGYDIYRQGPPADLPV------------- 310

  Fly   323 GNFIKSSI------------------IYRDI-------IP---LTKMLW-YPFVLCISTTSLFPL 358
              |:.||.                  ::||:       ||   .|...| |.|::
  Fly   311 --FLSSSCTHVPHTFTQIAEQMDTLDLWRDVAFEKNLMIPGCHYTDKRWAYQFLV---------- 363

  Fly   359 AAFFLHTLPGYFFDLLLRLKGRKPILVDLYRKIHKNIAVLGPFSSTTWNFDMTNTMELREAMSKQ 423
              |....||....|||||:.|:||:|:...||.::.:.|:.||....|:....:.|   |.:||.
  Fly   364 --FTKQILPALILDLLLRIFGQKPVLMSAVRKAYQTLEVMQPFMFNNWDSPGVSDM---ETLSKH 423

  Fly   424 -DRNLYDFD----------MAQLDWNDYFKAAMYGMRLYIGKEKPTAESIAKGLKLRMRLKVLHY 477
             :.:.::||          :.|...|     .::.:|.::.:|.|.....:|.:   :|:||..|
  Fly   424 GEGSAFNFDAFNHPDIHGLVIQSCSN-----MLHSIRTHLLREDPKTLERSKRI---LRIKVFLY 480

  Fly   478 AFASSLVALAGYILYSL 494
            ..      |..::||.|
  Fly   481 RL------LRLFLLYKL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17560	NP_650567.1	PLN02996	1..441	CDD:215538	135/482 (28%)
		FAR-N_SDR_e	12..327	CDD:187547	96/317 (30%)
		Sterile	364..454	CDD:281068	26/100 (26%)
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	98/330 (30%)
FarO	NP_652021.1	FAR_C	379..>410	CDD:296071	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466752
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26995
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.860