DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17560 and CG12268

DIOPT Version :9

Sequence 1:	NP_650567.1	Gene:	CG17560 / 42022	FlyBaseID:	FBgn0038450	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	174/505 - (34%)
Similarity:	275/505 - (54%)	Gaps:	28/505 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSEIQGFFKNKTVFLTGGTGFLGKVIIEKLLRT-TEVNRIYSLIRPKRGVPIEDRITTWAKDPVF 65
            :|:|..|:.|||:.:||.|||:|||::|||||: .::|.||.|||.|:||....|...:.|..:|
  Fly    12 ESDIAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQYFKCVIF 76

  Fly    66 EVLLRTKPDALQRVCPIAGDCLDPDLGISQSDQRILTAEVQIVIHGAATVRFDEALHISLAINVR 130
            ..||...|..:.:|..:.||.|:||||:|.:|...|.:.|::|.|.||.||||:.|...:.:||.
  Fly    77 GKLLEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRPMVMMNVV 141

  Fly   131 ATRLMLQLAKQMTQLVSFVHVSTAYSNCVVHDIAERFYPEHLNCSSDKILAVGELVSNKLLDAME 195
            .|..:|:||::|:||.:.|||||:|..|....:.||.||...|..|  |:.:.|.:.::.|..:.
  Fly   142 GTLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFS--IIEMVETMDDEALAEIT 204

  Fly   196 PSLVGSFPNTYTYTKALAEDVILREAGNLPLSIFRPAIIMSTYKEPLVGWVDNLFGPLALCFGGA 260
            |.|:...||||.|:|||:||:|.|....||:.|.||:|:.:...|||.||::.:.||..|..|.|
  Fly   205 PKLLNGLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGLMIGAA 269

  Fly   261 RGIMRVTTVDPSAKISLVPADYCVNVALACAWRTAEISVQNG-KVTTPPIYAFAPSENNLMSYGN 324
            ||::|....:|....:::|.|..:|..:.|.::..:.|.:.| |.|.........|...|||:|:
  Fly   270 RGVIRSMHCNPDYASTVIPVDKAINGMILCGYQRGKASQEKGNKQTGVEFCNLCISSKALMSWGD 334

  Fly   325 FIKSSIIYRDIIPLTKMLWYP----------FVLCISTTSLFPLAAFFLHTLPGYFFDLLLRLKG 379
            .|::...:....||:..||||          .:.|:          .|.|.||.||.|..|.:.|
  Fly   335 SIETGRRFFYETPLSFALWYPGGSIKKNYYHHLFCV----------IFFHYLPAYFIDFWLLVFG 389

  Fly   380 RKPILVDLYRKIHKNIAVLGPFSSTTWNFDMTNTMELREAMSKQDRNLYDFDMAQLDWNDYFKAA 444
            :||.|:::.||:...:.:|..:::..|.|......|:...:|..|::|:|..:.|::|..|....
  Fly   390 QKPFLLNVQRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQVNWETYISNY 454

  Fly   445 MYGMRLYI-GKEKPTAESIAKGLKLRMRLKVLHYAFASSLVALAGYILYS 493
            :.|||.|| |:.:.|.....|.|:   ||.:|.:.......:|:.:.|::
  Fly   455 IVGMRTYILGESEDTLPQARKVLR---RLYILDWVSKVLFFSLSFWFLWT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17560	NP_650567.1	PLN02996	1..441	CDD:215538	159/450 (35%)
		FAR-N_SDR_e	12..327	CDD:187547	123/316 (39%)
		Sterile	364..454	CDD:281068	29/90 (32%)
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	164/462 (35%)
		FAR-N_SDR_e	22..347	CDD:187547	124/326 (38%)
		FAR_C	372..463	CDD:176924	29/90 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466770
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.900