Protein Alignment CG10345 and SCARB2

DIOPT Version :10

• Sequence 1: NP_650563.2
• Gene: CG10345 / 42017
• FlyBaseID: FBgn0027562
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_005497.1
• Gene: SCARB2 / 950
• HGNCID: 1665
• Length: 478
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 121/439 - (27%)
• Similarity: 206/439 - (46%)
• Gaps: 37/439 - (8%)

  Fly    17 SAALGMTLLFFGSLVIISDPLQSILDTQLS----LKPGTLLHRLWLLPPLDVYINVYMFNYTNVD 77
            :..|.:.||.....::::...|..:|..:.    |:.||.....|..|||.||...|.||.||.:
Human     9 AGTLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPE 73

  Fly    78 EFTSGRASKLQLQEVGPYVYKEVLSNHNVTYNESNNTITYSPKREYVFAPERSVGDPKIDRIRAP 142
            |...|...:  ::|||||.|:|:.:..|:.:.::..||:....:.|||..::||||||||.||..
Human    74 EILRGETPR--VEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTL 136

  Fly   143 NIPLMGVTTLASSLSMFAALGLSAITRQLNSQPMLEMSVHDYMWGYEDHLVELASRFVPNWIDFS 207
            |||::  |.:..|...|....:.|:.:....:..:..:|.:.:|||:|.::.|...|.|   |.|
Human   137 NIPVL--TVIEWSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEILSLIHVFRP---DIS 196

  Fly   208 S-FGIMEKLFREGNESNVFNMNLPEPKDKYGMRMTDAPRGYTVDSINGERGFKGWQYNEETNGTM 271
            . ||    ||.|.|.:|..:......:|.| :..|      .:...||:.....|..::
Human   197 PYFG----LFYEKNGTNDGDYVFLTGEDSY-LNFT------KIVEWNGKTSLDWWITDK------ 244

  Fly   272 CNRIWGSHDATLFPLDMDENDEFFLYRRTFCRRLPVKFNRTTTFNGLDAFEFVMEPDSFDSEVDN 336
            ||.|.|:...:..|| :.:::..:::...|||.:.:.|:...:..||.||.:.:..:...:..||
Human   245 CNMINGTDGDSFHPL-ITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDN 308

  Fly   337 ANSSCYC-KNNRCLKKGVGNVSPCYYNIPLAITYPHFMHADPSLLEPFDGLQPNVSRFTSTFV-V 399
            |.   :| ....||..||.|||.|....|:.:::|||..||...:...:|:.|| .....||| :
Human   309 AG---FCIPEGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPN-QEDHETFVDI 369

  Fly   400 QPQLGAPMQGTHLRLQANQVVGKVNFNRMMTPFENMILPLLWVDLNIDV 448
            .|..|..::... |.|.|..|.|::..........|:.|:::::.::.:
Human   370 NPLTGIILKAAK-RFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHI 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10345	NP_650563.2	CD36	19..490	CDD:460076	121/437 (28%)
SCARB2	NP_005497.1	CD36	28..457	CDD:460076	118/420 (28%)
		Important for interaction with GBA1	155..191		7/35 (20%)