DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10345 and CD36

DIOPT Version :9

Sequence 1:	NP_650563.2	Gene:	CG10345 / 42017	FlyBaseID:	FBgn0027562	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens

Alignment Length:	456	Identity:	117/456 - (25%)
Similarity:	204/456 - (44%)	Gaps:	65/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RNAKLLRSAALGMTLLFFGSLVI-ISDPL-QSILDTQLSLKPGTLLHRLWLLPPLDVYINVYMFN 72
            ||..|:..|.:|..|..||.::: :.|.| |..:..|:.|:.||:..:.|:....:||...::|:
Human     5 RNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFD 69

  Fly    73 YTNVDEFTSGRASKLQLQEVGPYVYK-EVLSNHNVTYNESNNTITYSPKREYVFAPERSVGDPKI 136
            ..|..|... .:|.:|:::.|||.|: ..|:..|||.:..:||:::......:|.|..|||
Human    70 VQNPQEVMM-NSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVG---- 129

  Fly   137 DRIRAPNIPLMGVTTLASS---LSMFAALGLSAITRQLNSQPMLEMSVHDYMWGYEDHLVELASR 198
              ..|.|..::.:...|:|   .:.|..:.|:::..:..|......::.:.:|||.|..:.|...
Human   130 --TEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLWGYRDPFLSLVPY 192

  Fly   199 FVPNWIDFSSFGIMEKLFREGNES-----NVFNMNLPEPKDKYGMRMTDAPRGYTVDSINGERGF 258
            .|...:.         ||...|.:     .|||     .||       :..:...:|:..|:|..
Human   193 PVTTTVG---------LFYPYNNTADGVYKVFN-----GKD-------NISKVAIIDTYKGKRNL 236

  Fly   259 KGWQYNEETNGTMCNRIWGSHDATLFPLDMDENDEFFLYRRTFCRRLPVKFNRTTTFNGLDAFEF 323
            ..|:       :.|:.|.|: ||..||..::::.....:....||.:...|.......|:..:.|
Human   237 SYWE-------SHCDMINGT-DAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRF 293

  Fly   324 VMEPDSFDSEVDNANSSCYCK----NNRCLKKGVGNVSPCYYNIPLAITYPHFMHADPSLLEPFD 384
            |:...:|.|.|:|.::.|:|.    :..|...||.::|.|....|:.|:.|||::|.|.:.||.|
Human   294 VLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPID 358

  Fly   385 GLQPNVSRFTSTFVVQPQLGAPMQGTHLRLQANQVV---GKV----NFNRMMTPFENMILPLLWV 442
            ||.||.....:...::|..|..:|... |||.|.:|   .|:    |..|      |.|:|:||:
Human   359 GLNPNEEEHRTYLDIEPITGFTLQFAK-RLQVNLLVKPSEKIQVLKNLKR------NYIVPILWL 416

  Fly   443 D 443
            :
Human   417 N 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10345	NP_650563.2	CD36	21..488	CDD:279474	113/445 (25%)
CD36	NP_000063.2	CD36	14..463	CDD:395898	113/447 (25%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		7/26 (27%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820