DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10345 and scarb2a

DIOPT Version :9

Sequence 1:	NP_650563.2	Gene:	CG10345 / 42017	FlyBaseID:	FBgn0027562	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_775366.1	Gene:	scarb2a / 192340	ZFINID:	ZDB-GENE-020419-29	Length:	531	Species:	Danio rerio

Alignment Length:	522	Identity:	135/522 - (25%)
Similarity:	231/522 - (44%)	Gaps:	71/522 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QRNAKLLRSAALGMTLLFFGSLVIISDPLQSILDTQLSLKPGTLLHRL-----WLLPPLDVYINV 68
            :|:..:..:..:...||..|..::::...|:::..::. |..||....     |:.||..||:..
Zfish     3 RRSCTIYATGIVCAHLLILGIALLLAQVFQTMIQERIK-KEITLAENSRVLDGWINPPPPVYMQY 66

  Fly    69 YMFNYTNVDEFTSGRASKLQLQEVGPYVYKEVLSNHNVTYNESNNTITYSPKREYVFAPERSVGD 133
            :.||.||.|||.:|: .|.::.::|||.|:|.....||||.|:...|..:..:.:||....|.||
Zfish    67 FFFNVTNPDEFLAGK-EKAKVTQMGPYTYREYRPRENVTYLENGTKIFATNPKSFVFLRNMSAGD 130

  Fly   134 PKIDRIRAPNIPLMGVTTLASSLSMFAALGLSAITRQLNSQPMLEMSVHDYMWGYEDHLVELASR 198
            |::||:...|||::.|....:|.|.|....:|.....:.....:..:||:.:||::|.|:.....
Zfish   131 PEVDRVTTVNIPMIAVMNELNSYSFFVRTAVSMYMGSMGMGLFMNRTVHEILWGFKDPLLTKLHA 195

  Fly   199 FVPNWIDFSSFGIM---------EKLFREGNESNVFNMNLPEPKDKYGMRMTDAPRGYTVDSING 254
            ..|. :| ..||:|         |.:|..| |.|..|         ||          .:|:.||
Zfish   196 MRPE-VD-EHFGLMYNKNGTHEGEFVFHTG-EKNYMN---------YG----------KIDTWNG 238

  Fly   255 ERGFKGWQYNEET--NGTMCNRIWGSHDATLFPLDMDENDEFFLYRRTFCRRLPVKFNRTTTFNG 317
            ......|..|:..  |||         |.::|...:...:..:::....||.:.:.:.|.....|
Zfish   239 ISQMNWWSSNQSNMINGT---------DGSVFHTFLSRKELLYIFAADLCRSIHLGYVRDMEVKG 294

  Fly   318 LDAFEFVMEPDSFDSEVDNANSSCYC-KNNRCLKKGVGNVSPCYYNIPLAITYPHFMHADPSLLE 381
            :.||.|....|......:|..::.:| ....||.|||..||.|....|:.:::|||..||...:.
Zfish   295 IPAFRFAPPSDVLAPPDENPANAGFCVPAGDCLGKGVLKVSVCRQGAPIVVSFPHFYQADERYIN 359

  Fly   382 PFDGLQPNVSRFTSTFVVQPQLGAPMQGTHLRLQANQVVGKV-NFNRMMTPFEN-MILPLLWVD- 443
            ..:|:.||.....:...:.|..|.|::... |.|.|.::.:| .|..  |.|.| .|.|:::|:
Zfish   360 AIEGMNPNEEEHETYLDINPTTGVPIRACK-RAQLNIILKRVRGFPN--TKFLNETIFPIMYVNE 421

  Fly   444 -LNID---VLCLTLRLLIHGIKWGFPLLQWSAALGMLLAGVYQLCSALLLCFWPTARQFQKVDQV 504
             ..||   ...:.:.|||..:...||::  ..|||::|         |::..:...|..|:.::|
Zfish   422 TATIDDESAAQMRMLLLIVTVVSNFPVI--ILALGVIL---------LVVLIFLVCRNRQRKNEV 475

  Fly   505 ER 506
            :|
Zfish   476 KR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10345	NP_650563.2	CD36	21..488	CDD:279474	129/490 (26%)
scarb2a	NP_775366.1	CD36	30..463	CDD:279474	127/479 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020