DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14892 and TMPRSS5

DIOPT Version :10

Sequence 1:NP_650562.1 Gene:CG14892 / 42016 FlyBaseID:FBgn0038447 Length:442 Species:Drosophila melanogaster
Sequence 2:NP_110397.2 Gene:TMPRSS5 / 80975 HGNCID:14908 Length:457 Species:Homo sapiens


Alignment Length:410 Identity:103/410 - (25%)
Similarity:145/410 - (35%) Gaps:160/410 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 WQIP---ATSTATLSWLCLLLLLPSSRQFETDCGCRPARRGPRIIAGAATNEGQFPWQASLELLH 102
            || |   .||...:|..|            ::||.||.  ..||:.|.:...|::|||||:    
Human   190 WQ-PRNNCTSGQVVSLRC------------SECGARPL--ASRIVGGQSVAPGRWPWQASV---- 235

  Fly   103 PSLGFLGHWCGAVLIHQYWILSAAHCVHNDLFNLPIPPLWTVVLGEHDRDVESGNEQRIPVEKIV 167
             :||| .|.||..::...|:::||||:|:  |.|.....|.|..|.........::..: ||:|:
Human   236 -ALGF-RHTCGGSVLAPRWVVTAAHCMHS--FRLARLSSWRVHAGLVSHSAVRPHQGAL-VERII 295

  Fly   168 MHHRY--HNFKHDVVLMKLSKPADLTRASNIRRICLPFLLAESPDQAQSETVSPPSSADEDVLIQ 230
            .|..|  .|..:||.|::|.  ..|..:..:..:|||                            
Human   296 PHPLYSAQNHDYDVALLRLQ--TALNFSDTVGAVCLP---------------------------- 330

  Fly   231 QLELEDVPEKIDNFLRSVQSRRRYRNVTAPSMKELMNMKILSRMRQALAQRSPRSHKRSRRRNDK 295
                                                                             
Human   331 ----------------------------------------------------------------- 330

  Fly   296 LMKLGPRRDSDDSAEQKHPKVSDEPKEIAFVDCVATGWGKANISGDLSNQLLK-TQVPLHQNGRC 359
                        :.||..||.|         .|..:|||..:.|...|:.:|: |.|||.....|
Human   331 ------------AKEQHFPKGS---------RCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLC 374

  Fly   360 RDAYGSFVNIHGG-----HLCAGKLNGEGGTCVGDSGGPLQCRLSRDG-PWILVGVTSFGSGCAL 418
            ..:.     ::.|     .||||.|:|....|.|||||||.|   .|| .|.||||.|:|.|||.
Human   375 NSSC-----VYSGALTPRMLCAGYLDGRADACQGDSGGPLVC---PDGDTWRLVGVVSWGRGCAE 431

  Fly   419 EGFPDVYTRTSYYMKWIEDT 438
            ...|.||.:.:.::.||.||
Human   432 PNHPGVYAKVAEFLDWIHDT 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14892NP_650562.1 Tryp_SPc 81..438 CDD:238113 89/365 (24%)
TMPRSS5NP_110397.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
SRCR_2 116..213 CDD:464747 9/35 (26%)
Tryp_SPc 217..448 CDD:214473 88/363 (24%)
Blue background indicates that the domain is not in the aligned region.

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