Protein Alignment CG14891 and FBXL20

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001357137.2
• Gene: FBXL20 / 84961
• HGNCID: 24679
• Length: 438
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 75/303 - (24%)
• Similarity: 123/303 - (40%)
• Gaps: 58/303 - (19%)

  Fly   238 NITNISLRRCNLKDAHIYCLQM---LSKLKSLDIRENFSIKGDSLKSL----PISLEILNVSGCV 295
            ||..::|..|. |.....|..:   .|||:.||:....||...|||:|    |: ||.||:|.|
Human   120 NIEVLNLNGCT-KTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPL-LEQLNISWC- 181

  Fly   296 DLSPKCLIQ--LAALSHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQLG---- 354
            |...|..||  :.....|:.|...|..:.  ::|....:..:||.|..|.|...:.:...|
Human   182 DQVTKDGIQALVRGCGGLKALFLKGCTQL--EDEALKYIGAHCPELVTLNLQTCLQITDEGLITI 244

  Fly   355 --GLSRLHTLVIHSSAQLDYHVNNVLLTSIAESY-SLRHLEILDSFGPMSDTSF----------- 405
              |..:|.:|.....:    ::.:.:|.::.::. .||.||:. ....::|..|
Human   245 CRGCHKLQSLCASGCS----NITDAILNALGQNCPRLRILEVA-RCSQLTDVGFTTLARNCHELE 304

  Fly   406 --DLSIFSQLKE--LRTLILHNQNFTTLHLM--------GLQKLST-------LEFLDLSGSPNL 451
              ||....|:.:  |..|.:|......|.|.        |::.|..       ||.::|...|.:
Human   305 KMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLI 369

  Fly   452 SNEVVAKLTKSLSGLRRLKVDFCPLITRQLTKILEGN-PKLQV 493
            ::..:..| ||...|.|:::..|..|||...|.|..: |.::|
Human   370 TDASLEHL-KSCHSLERIELYDCQQITRAGIKRLRTHLPNIKV 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381
		LRR	<235..>463	CDD:443914	64/270 (24%)
		leucine-rich repeat	239..262	CDD:275381	5/25 (20%)
		leucine-rich repeat	263..285	CDD:275381	10/25 (40%)
		leucine-rich repeat	286..338	CDD:275381	15/53 (28%)
		leucine-rich repeat	339..387	CDD:275381	8/54 (15%)
		leucine-rich repeat	388..415	CDD:275381	9/39 (23%)
		leucine-rich repeat	416..439	CDD:275381	7/30 (23%)
		leucine-rich repeat	440..465	CDD:275381	7/24 (29%)
FBXL20	NP_001357137.2	F-box_FBXL2-like	24..68	CDD:438887
		leucine-rich repeat	67..94	CDD:275381
		AMN1	95..291	CDD:187754	46/180 (26%)
		leucine-rich repeat	95..114	CDD:275381
		leucine-rich repeat	121..146	CDD:275381	5/25 (20%)
		leucine-rich repeat	147..172	CDD:275381	9/24 (38%)
		leucine-rich repeat	173..198	CDD:275381	10/25 (40%)
		leucine-rich repeat	199..224	CDD:275381	5/26 (19%)
		AMN1	222..396	CDD:187754	37/179 (21%)
		leucine-rich repeat	225..250	CDD:275381	5/24 (21%)
		leucine-rich repeat	251..276	CDD:275381	3/28 (11%)
		leucine-rich repeat	277..302	CDD:275381	6/25 (24%)
		leucine-rich repeat	303..328	CDD:275381	6/24 (25%)
		leucine-rich repeat	329..357	CDD:275381	4/27 (15%)
		leucine-rich repeat	358..382	CDD:275381	7/24 (29%)
		leucine-rich repeat	383..408	CDD:275381	8/24 (33%)