Protein Alignment CG14891 and FBXL18

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001308142.1
• Gene: FBXL18 / 80028
• HGNCID: 21874
• Length: 801
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 87/420 - (20%)
• Similarity: 160/420 - (38%)
• Gaps: 91/420 - (21%)

  Fly   114 LPITDDIWWKVLDYL-SLNERLNFAASCERFQAIYELDSHRINHVLNMKD-------VCTLTHRV 170
            |..:|:|...:|.:: |.:..||...:|.:..|:. ||...|:.||..||       |..|...:
Human    29 LGFSDEILLHILSHVPSTDLILNVRRTCRKLAALC-LDKSLIHTVLLQKDYQASEDKVRQLVKEI 92

  Fly   171 IKRLMLLSGKHIHCVTGGPLHPNWPYLTEFVQLLGVS---CPNLTELSFFKISVSLAHMTHLFDG 232
            .:.:..||....:.:.|..:.    ::.....|:.|:   | :||.|...|:..:|.|:..|...
Human    93 GREIQQLSMAGCYWLPGSTVE----HVARCRSLVKVNLSGC-HLTSLRLSKMLSALQHLRSLAID 152

  Fly   233 ANGLINITNISLRRCNLKDAHIYCLQMLSKLKSLD---IRENFSIKG--DSLKSLPISLEILNVS 292
            .:...:.:.:|..          |...||:::.|.   ...::.:..  .||:.|.:..|||:.:
Human   153 VSPGFDASQLSSE----------CKATLSRVRELKQTLFTPSYGVVPCCTSLEKLLLYFEILDRT 207

  Fly   293 --GCVDLSPKCLIQLAALSHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQLGG 355
              |.: ||.:.::..:.:.|.:.||.           .|.|||......||:.|  ::.|:....
Human   208 REGAI-LSGQLMVGQSNVPHYQNLRV-----------FYARLAPGYINQEVVRL--YLAVLSDRT 258

  Fly   356 LSRLHTLVI-------HSSAQ---LDYHVNNVLLTSIA-------ESYSLRHLEILDSF------ 397
            ...||..:|       .|.|.   ||....||:|.::.       .|..|:|::..:.|
Human   259 PQNLHAFLISVPGSFAESGATKNLLDSMARNVVLDALQLPKSWLNGSSLLQHMKFNNPFYFSFSR 323

  Fly   398 GPMSDTSFDLSIFSQLKELRTLILHNQNFTTLHLMGLQKLSTLEFLDLSGSPNLSNEVVAKLTKS 462
            ..:|.......:.:..|:||:|       .:|:|.|.....:.:.|......::.:.::..|..|
Human   324 CTLSGGHLIQQVINGGKDLRSL-------ASLNLSGCVHCLSPDSLLRKAEDDIDSSILETLVAS 381

  Fly   463 LSGLRRLKVD-------------FCPLITR 479
            ...||.|.:.             .|.|:.|
Human   382 CCNLRHLNLSAAHHHSSEGLGRHLCQLLAR 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381	7/25 (28%)
		LRR	<235..>463	CDD:443914	49/257 (19%)
		leucine-rich repeat	239..262	CDD:275381	3/22 (14%)
		leucine-rich repeat	263..285	CDD:275381	4/26 (15%)
		leucine-rich repeat	286..338	CDD:275381	13/53 (25%)
		leucine-rich repeat	339..387	CDD:275381	15/64 (23%)
		leucine-rich repeat	388..415	CDD:275381	4/32 (13%)
		leucine-rich repeat	416..439	CDD:275381	6/22 (27%)
		leucine-rich repeat	440..465	CDD:275381	3/24 (13%)
FBXL18	NP_001308142.1	F-box_FBXL18	28..71	CDD:438900	12/42 (29%)
		FBXL18_LRR	85..678	CDD:466163	71/363 (20%)
		leucine-rich repeat	345..384	CDD:275381	7/45 (16%)
		leucine-rich repeat	385..414	CDD:275381	6/27 (22%)
		leucine-rich repeat	415..484	CDD:275381
		leucine-rich repeat	451..476	CDD:275381
		leucine-rich repeat	485..532	CDD:275381
		leucine-rich repeat	533..559	CDD:275381
		leucine-rich repeat	560..589	CDD:275381
		leucine-rich repeat	590..615	CDD:275381
		leucine-rich repeat	616..640	CDD:275381