Protein Alignment CG14891 and FBXL15

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: XP_054222687.1
• Gene: FBXL15 / 79176
• HGNCID: 28155
• Length: 387
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 73/320 - (22%)
• Similarity: 112/320 - (35%)
• Gaps: 81/320 - (25%)

  Fly   104 EESGTLSAYDLPITDDIWWKVLDYLSLNERLNFAASCERFQAIYELDSHRINHVLNMK-----DV 163
            :|.|.:...|||..|.:...||:.:.|.:.|........|:::.:|      |:..::     .|
Human    99 QEPGAVRFLDLPWEDVLLPHVLNRVPLRQLLRLQRVSRAFRSLVQL------HLAGLRRFDAAQV 157

  Fly   164 CTLTHRVIKRLMLLSGKHIHCVTGGPLHPNW-------PYLTEFVQLLGVS-------------- 207
            .....|.....:|...:.:..:...|.| .|       |.|....||..|:
Human   158 GPQIPRAALARLLRDAEGLQELALAPCH-EWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGA 221

  Fly   208 ----CPNLTELSFFKISVSLAHMTHLFDG--ANGLIN----ITNISLRRC-NLKD-AHIYCLQML 260
                ||.|..|       ||||...: ||  ..||.:    :..:.|..| .||| |.:|..|.
Human   222 LAEGCPRLQRL-------SLAHCDWV-DGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQR- 277

  Fly   261 SKLKSLDIRENFSIKGDSLKSLPISLEILNVSGCV--DLSPKCLIQLAALSHLRELRCPGIVKFA 323
                          :|..|:||.:::. .||....  :|:..|       ..|..|...|.::..
Human   278 --------------RGAGLRSLSLAVN-ANVGDAAVQELARNC-------PELHHLDLTGCLRVG 320

  Fly   324 KDNELYGRLAHYCPMLEVLELTDFMNVIQLGGLSRLHTLVIHSSAQLDYHVNNVLLTSIA 383
            .|.  ...||.|||:|..|.:....:|.: ..||||....:....:...|...|||..:|
Human   321 SDG--VRTLAEYCPVLRSLRVRHCHHVAE-SSLSRLRKRGVDIDVEPPLHQALVLLQDMA 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381	9/27 (33%)
		LRR	<235..>463	CDD:443914	39/157 (25%)
		leucine-rich repeat	239..262	CDD:275381	8/24 (33%)
		leucine-rich repeat	263..285	CDD:275381	4/21 (19%)
		leucine-rich repeat	286..338	CDD:275381	12/53 (23%)
		leucine-rich repeat	339..387	CDD:275381	12/45 (27%)
		leucine-rich repeat	388..415	CDD:275381
		leucine-rich repeat	416..439	CDD:275381
		leucine-rich repeat	440..465	CDD:275381
FBXL15	XP_054222687.1	F-box_FBXL15	106..147	CDD:438898	11/46 (24%)
		leucine-rich repeat	149..175	CDD:275381	3/25 (12%)
		FBXL3_LRR-like	<158..233	CDD:480268	14/82 (17%)
		leucine-rich repeat	176..202	CDD:275381	5/26 (19%)
		leucine-rich repeat	203..228	CDD:275381	3/24 (13%)
		AMN1	<226..>353	CDD:187754	42/160 (26%)
		leucine-rich repeat	229..254	CDD:275381	10/32 (31%)
		leucine-rich repeat	255..281	CDD:275381	9/40 (23%)
		leucine-rich repeat	282..307	CDD:275381	7/32 (22%)
		leucine-rich repeat	308..332	CDD:275381	7/25 (28%)