Protein Alignment CG14891 and Fbxl17

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_056609.1
• Gene: Fbxl17 / 50758
• MGIID: 1354704
• Length: 701
• Species: Mus musculus
• Alignment Length: 383
• Identity: 86/383 - (22%)
• Similarity: 142/383 - (37%)
• Gaps: 120/383 - (31%)

  Fly   121 WWKVLDYLS----LNERLNFAASCERFQAIYELDSHRINHVLNMKD--VCTLTHR-------VIK 172
            :||.||..|    .:|.|...||  |.|.|.|::   |:...::.|  ||.|..:       ...
Mouse   361 FWKQLDLSSRQQVTDELLEKIAS--RSQNIIEIN---ISDCRSLSDSGVCVLAFKCPGLLRYTAY 420

  Fly   173 RLMLLSGKHI-----HCVTGGPLH-PNWPYLT-EFVQLLGVSCPNLTELSF---FKISVSLAHMT 227
            |...||...|     ||.....:| .|...|| |.::.||..|..|.::.|   :|||
Mouse   421 RCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQCYKIS------- 478

  Fly   228 HLFDGANGLINITNISLRRCNLKDAHIYCLQMLSKLKSLDIRENFSIKGDSLKSL----PISLEI 288
                 ..|:|.|..             .||    ||:.:.::||..:...|:|:.    | .|:.
Mouse   479 -----DEGMIVIAK-------------SCL----KLQRIYMQENKLVTDQSVKAFAEHCP-ELQY 520

  Fly   289 LNVSGCVDLSPKCLIQLAALSHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQL 353
            :...|| .::.|.:|.|..|.:|..|....|.:.  |||....:...|..|..|.|.
Mouse   521 VGFMGC-SVTSKGVIHLTKLRNLSSLDLRHITEL--DNETVMEIVKRCKNLSSLNLC-------- 574

  Fly   354 GGLSRLHTLVIHSSAQLDYHVNNVLLTSIAESYSLRHLEILDSFGPMSDTSFDLSIFSQLKELRT 418
                            |::.:|:            |.:|::...|               :.|:.
Mouse   575 ----------------LNWIIND------------RCVEVIAKEG---------------QNLKE 596

  Fly   419 LILHNQNFTTLHLMGLQKLS-TLEFLDLSGSPNLSNE---VVAKLTKSLSGLRRLKVD 472
            |.|.:...|...|:.:.:.| |:|.:|:.....::::   ::|:.:|||..|..::.|
Mouse   597 LYLVSCKITDYALIAIGRYSVTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCD 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381	6/28 (21%)
		LRR	<235..>463	CDD:443914	45/235 (19%)
		leucine-rich repeat	239..262	CDD:275381	3/22 (14%)
		leucine-rich repeat	263..285	CDD:275381	6/25 (24%)
		leucine-rich repeat	286..338	CDD:275381	14/51 (27%)
		leucine-rich repeat	339..387	CDD:275381	5/47 (11%)
		leucine-rich repeat	388..415	CDD:275381	3/26 (12%)
		leucine-rich repeat	416..439	CDD:275381	6/23 (26%)
		leucine-rich repeat	440..465	CDD:275381	6/27 (22%)
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..93
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	279..321
		F-box_FBXO13	320..368	CDD:438864	4/6 (67%)
		leucine-rich repeat	362..387	CDD:275381	10/26 (38%)
		leucine-rich repeat	388..413	CDD:275381	7/27 (26%)
		AMN1	411..573	CDD:187754	47/194 (24%)
		leucine-rich repeat	414..439	CDD:275381	6/24 (25%)
		leucine-rich repeat	440..465	CDD:275381	8/24 (33%)
		leucine-rich repeat	466..491	CDD:275381	10/53 (19%)
		leucine-rich repeat	492..517	CDD:275381	6/25 (24%)
		leucine-rich repeat	545..567	CDD:275381	6/23 (26%)
		leucine-rich repeat	568..593	CDD:275381	8/75 (11%)
		leucine-rich repeat	594..618	CDD:275381	6/23 (26%)
		leucine-rich repeat	619..644	CDD:275381	3/24 (13%)
		leucine-rich repeat	645..670	CDD:275381	3/10 (30%)