Protein Alignment CG14891 and fbxl6

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001296447.1
• Gene: fbxl6 / 323163
• ZFINID: ZDB-GENE-060810-162
• Length: 564
• Species: Danio rerio
• Alignment Length: 589
• Identity: 119/589 - (20%)
• Similarity: 204/589 - (34%)
• Gaps: 188/589 - (31%)

  Fly     4 MRPDIKNFYIERGVAYTEDREVVRQLTISGSRRFLKYQLLKYFSIFGKVEKLHWKKKKRSGSVLF 68
            :||   |:.::.|    ||..::.....||.      .:.|.....||.:|.: ||.|..||...
Zfish    59 VRP---NYTVQEG----EDMLLIISNISSGD------SVWKPKRKVGKKKKTN-KKAKTKGSTSK 109

  Fly    69 YE-ATHAAKALYCTKHTIDGHDLYLQASTS----W-HPTPVE-----------ESGTL------- 109
            .| |....:.|...:.|.|.||:...|.|.    | ...|:|           :.|.:
Zfish   110 KEKAPVKTEVLKVREETDDKHDVMDSAKTDRFDHWGQSLPLEILVKIFQFAVFQDGAVPLLCRVG 174

  Fly   110 -------SAYDLPITDDIW--------W----------------KVLDYLSLNERLNFAASCERF 143
                   .|...||   :|        |                ..:|:|:.|.
Zfish   175 RVCRLWNGAASSPI---LWRSVSIGYCWIEPGKSQLPGTEQKIKNTVDWLAENR----------- 225

  Fly   144 QAIYELDSHRINHVLNMKDVCTLTHRVIKRLMLLSGKHIHCVTGGPLHPNWPYLTE-FVQLLGVS 207
              :::|....:.|.  .|:|..:..:|.:..:.|....:...||         :|| ..|.||..
Zfish   226 --LFQLREFSLCHW--KKNVDYVIQKVSQSCLSLHSLKLSYCTG---------MTEKAFQNLGAD 277

  Fly   208 CPNLTELSFFKISVSLAHMTHLFDGANGLIN--------ITNISLRRCNLKDAHIYCLQMLSK-- 262
            |.:|.::          ::.|.....:||::        |..|........|.   .|..|||
Zfish   278 CQSLEDI----------NVQHSEINVDGLVSFLEAYGNQIKKIYFTHSTKSDK---LLSALSKGC 329

  Fly   263 ---LKSLDIRENFSIKGDSLKSLPISLEILNVSGCVDLSPKCLIQLAALSH-------------- 310
               |:.|:|  |..:.| ....|||.::.|.: ||..|....|:.:.|:..
Zfish   330 CPELRLLEI--NTKLDG-GYSQLPICIQGLQI-GCPKLQTFRLMNVTAVPKMIRNIPSSTCGFPM 390

  Fly   311 LRELRC--PGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQLGGLSRLHTLVIHSSAQLD-- 371
            |.|| |  .....|..||:| ..:.|..|.|.||:|.....:...|    |:.|   ...:|:
Zfish   391 LEEL-CIATSFHSFMTDNDL-NNVLHGSPNLRVLDLRGGSRITPTG----LYAL---PCERLECF 446

  Fly   372 ----YHVNNVLLTS------IAESYS--LRHLEILDSFGPMSDTSFDLSIFSQLKELRTLILHNQ 424
                |..:|.::.|      :|:.:|  ||.|::.:.  |.|:...::::..
Zfish   447 YWGLYFNSNTMVASKKGIHMLAQKWSNTLRELDLANQ--PFSEEDLEIAMGH------------- 496

  Fly   425 NFTTLHLMGLQKLSTLEFLDLSGSPNLSNEVVAKLTKSLSGLRRLKVDFCPLITRQLTKILEGNP 489
               ..|.:|::...:   |:|||: .:::..:..|......|:.|.:..|..:.|.|.::..|..
Zfish   497 ---LAHSVGVEFFRS---LNLSGT-KITSSALRLLINQAPALKYLNLSSCRYLPRGLKRLYHGQE 554

  Fly   490 KLQV 493
            .:|:
Zfish   555 DIQL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636	16/51 (31%)
		leucine-rich repeat	211..237	CDD:275381	3/25 (12%)
		LRR	<235..>463	CDD:443914	58/270 (21%)
		leucine-rich repeat	239..262	CDD:275381	5/22 (23%)
		leucine-rich repeat	263..285	CDD:275381	7/21 (33%)
		leucine-rich repeat	286..338	CDD:275381	15/67 (22%)
		leucine-rich repeat	339..387	CDD:275381	12/59 (20%)
		leucine-rich repeat	388..415	CDD:275381	5/26 (19%)
		leucine-rich repeat	416..439	CDD:275381	2/22 (9%)
		leucine-rich repeat	440..465	CDD:275381	5/24 (21%)
fbxl6	NP_001296447.1	F-box_FBXL6	145..191	CDD:438891	6/48 (13%)
		AMN1	213..396	CDD:187754	45/224 (20%)
		leucine-rich repeat	229..254	CDD:275381	5/26 (19%)
		leucine-rich repeat	255..280	CDD:275381	9/33 (27%)
		leucine-rich repeat	281..306	CDD:275381	4/34 (12%)
		leucine-rich repeat	307..334	CDD:275381	7/29 (24%)
		leucine-rich repeat	335..362	CDD:275381	10/30 (33%)
		AMN1	<391..>542	CDD:187754	38/181 (21%)
		leucine-rich repeat	391..418	CDD:275381	9/28 (32%)
		leucine-rich repeat	419..438	CDD:275381	6/22 (27%)
		leucine-rich repeat	445..473	CDD:275381	4/27 (15%)
		leucine-rich repeat	475..505	CDD:275381	7/47 (15%)
		leucine-rich repeat	506..530	CDD:275381	5/27 (19%)