Protein Alignment CG14891 and Fbxl15

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001101073.1
• Gene: Fbxl15 / 309453
• RGDID: 1306444
• Length: 300
• Species: Rattus norvegicus
• Alignment Length: 327
• Identity: 75/327 - (22%)
• Similarity: 120/327 - (36%)
• Gaps: 85/327 - (25%)

  Fly   102 PVEES------GTLSAYDLPITDDIWWKVLDYLSLNERLNFAASCERFQAIYELDSHRINHVLNM 160
            |:|:|      |.:...|||..|.:...||:::.|.:.|........|:|:.:|...|:.. .:.
  Rat     4 PMEQSGGEQEPGAVRLLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAFRALVQLHLARLRR-FDA 67

  Fly   161 KDVCTLTHRVIKRLMLLSGKHIHCVTGGPLHPNW-------PYLTEFVQLLGVS----------- 207
            ..|.....|.....:|...:.:..:...|.| .|       |.|....||..|:
  Rat    68 AQVGPQIPRAALVRLLRDAEGLQELALAPCH-EWLLDEDLVPVLARNPQLRSVALAGCGQLSRRA 131

  Fly   208 -------CPNLTELSFFKISVSLAHMTHLFDG--ANGLIN----ITNISLRRC-NLKD-AHIYCL 257
                   ||.|..       :||||...: ||  ..||.:    :..:.|..| .||| |.:|..
  Rat   132 LGALAEGCPRLQR-------ISLAHCDWV-DGLALRGLADRCPALEELDLTACRQLKDEAIVYLA 188

  Fly   258 QML-SKLKSLDIRENFSIKGDS-----LKSLPISLEILNVSGCVDLSPKCLIQLAALSHLRELRC 316
            |.. :.|:||.:..|.:: ||:     .::.| .||.|:::||:.:.
  Rat   189 QRRGAGLRSLSLAVNANV-GDTAVQELARNCP-QLEHLDLTGCLRVG------------------ 233

  Fly   317 PGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQLGGLSRLHTLVIHSSAQLDYHVNNVLLTS 381
                     ::....||.|||.|..|.:....:|.: ..||||....:....:...|...|||..
  Rat   234 ---------SDGVRTLAEYCPALRSLRVRHCHHVAE-PSLSRLRKRGVDIDVEPPLHQALVLLQD 288

  Fly   382 IA 383
            :|
  Rat   289 MA 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381	8/27 (30%)
		LRR	<235..>463	CDD:443914	39/161 (24%)
		leucine-rich repeat	239..262	CDD:275381	8/25 (32%)
		leucine-rich repeat	263..285	CDD:275381	7/26 (27%)
		leucine-rich repeat	286..338	CDD:275381	9/51 (18%)
		leucine-rich repeat	339..387	CDD:275381	12/45 (27%)
		leucine-rich repeat	388..415	CDD:275381
		leucine-rich repeat	416..439	CDD:275381
		leucine-rich repeat	440..465	CDD:275381
Fbxl15	NP_001101073.1	F-box_FBXL15	19..62	CDD:438898	11/42 (26%)
		leucine-rich repeat	62..88	CDD:275381	3/26 (12%)
		FBXL3_LRR-like	<71..146	CDD:480268	13/82 (16%)
		leucine-rich repeat	89..115	CDD:275381	5/26 (19%)
		Interaction with SMURF1. /evidence=ECO:0000250	113..269		46/193 (24%)
		leucine-rich repeat	116..141	CDD:275381	3/24 (13%)
		AMN1	<139..>268	CDD:187754	43/166 (26%)
		leucine-rich repeat	142..167	CDD:275381	9/32 (28%)
		leucine-rich repeat	168..194	CDD:275381	8/25 (32%)
		leucine-rich repeat	195..220	CDD:275381	7/26 (27%)
		leucine-rich repeat	221..245	CDD:275381	8/50 (16%)