Protein Alignment CG14891 and FBXL6

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_036294.2
• Gene: FBXL6 / 26233
• HGNCID: 13603
• Length: 539
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 78/391 - (19%)
• Similarity: 124/391 - (31%)
• Gaps: 129/391 - (32%)

  Fly   171 IKRLMLLSGKHIHCVTGGPLHPNWPYLTEFVQLLGVSCPNLTELSFFKISVSLAHMTHLFDGANG 235
            ::||.|:..|       ..:||       .::|:|..||.||   |.|:|           |.:|
Human   196 LQRLTLIHWK-------SQVHP-------VLKLVGECCPRLT---FLKLS-----------GCHG 232

  Fly   236 LINITNISLRRCNLKDAHIYCLQMLSKLKSLDIRENF---------------------------- 272
            :            ..||.:...:...:|.|||::.:.
Human   233 V------------TADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQT 285

  Fly   273 -SIKGDSLKSLPISLEILNVS-------------------GCVDLSPKCLIQLAAL--------- 308
             :|.|..|.|....|::|.||                   ||..|....|:.|..|
Human   286 TAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLRLLNLMWLPKPPGRGVA 350

  Fly   309 -----SHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQLG-------GLSRLHT 361
                 ..|.||...........||:.|||.|..|.|.:|:|.....:...|       .|.:||.
Human   351 PGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLPCRELEQLHL 415

  Fly   362 LVIHSSAQLDYHVNNVLLTSIAESYSLRHLEILDSFGPMSDTSFDLSIFSQLKELRTLILHNQNF 426
            .:..:|.:|..........:....::||.|::........|....|:.|     |.|....:...
Human   416 GLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAF-----LSTPGGSHPAL 475

  Fly   427 TTLHLMGLQKLSTLEFLDLSGSPNLSNEVVAKLTKSLSGLRRLKVDFCPLITRQLTKILEGNPKL 491
            .:|:|.|.:...:.....:||.|               ||..|.::.|..:.|.|.:...|..::
Human   476 CSLNLRGTRVTPSTVSSVISGCP---------------GLLYLNLESCRCLPRGLKRAYRGLEEV 525

  Fly   492 Q 492
            |
Human   526 Q 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381	7/25 (28%)
		LRR	<235..>463	CDD:443914	54/296 (18%)
		leucine-rich repeat	239..262	CDD:275381	2/22 (9%)
		leucine-rich repeat	263..285	CDD:275381	8/50 (16%)
		leucine-rich repeat	286..338	CDD:275381	19/84 (23%)
		leucine-rich repeat	339..387	CDD:275381	9/54 (17%)
		leucine-rich repeat	388..415	CDD:275381	6/26 (23%)
		leucine-rich repeat	416..439	CDD:275381	5/22 (23%)
		leucine-rich repeat	440..465	CDD:275381	3/24 (13%)
FBXL6	NP_036294.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..111
		F-box_FBXL6	112..158	CDD:438891
		LRR 1	177..203		3/6 (50%)
		AMN1	185..398	CDD:187754	50/241 (21%)
		leucine-rich repeat	196..221	CDD:275381	9/38 (24%)
		LRR 2	204..229		12/52 (23%)
		leucine-rich repeat	222..247	CDD:275381	9/50 (18%)
		LRR 3	230..255		7/36 (19%)
		leucine-rich repeat	248..299	CDD:275381	8/50 (16%)
		LRR 4	281..307		7/25 (28%)
		leucine-rich repeat	300..329	CDD:275381	6/28 (21%)
		LRR 5	312..337		4/24 (17%)
		leucine-rich repeat	330..357	CDD:275381	4/26 (15%)
		LRR 6	341..365		4/23 (17%)
		AMN1	<357..508	CDD:187754	36/170 (21%)
		leucine-rich repeat	358..385	CDD:275381	9/26 (35%)
		LRR 7	368..393		10/24 (42%)
		leucine-rich repeat	386..409	CDD:275381	4/22 (18%)
		LRR 8	394..419		4/24 (17%)
		LRR 9	423..449		4/25 (16%)
		leucine-rich repeat	442..474	CDD:275381	8/36 (22%)
		LRR 10	453..481		6/32 (19%)
		leucine-rich repeat	475..499	CDD:275381	6/38 (16%)
		LRR 11	482..507		7/39 (18%)