Protein Alignment CG14891 and FBXL2

DIOPT Version :10

• Sequence 1: NP_650560.1
• Gene: CG14891 / 42013
• FlyBaseID: FBgn0038445
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: XP_054201991.1
• Gene: FBXL2 / 25827
• HGNCID: 13598
• Length: 479
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 77/300 - (25%)
• Similarity: 122/300 - (40%)
• Gaps: 61/300 - (20%)

  Fly   238 NITNISLRRC-NLKDAHIYCL-QMLSKLKSLDIRENFSIKGDSLKSLP---ISLEILNVSGCVDL 297
            ||.:::|..| .:.|:..|.| :..||||.||:....||...|||.:.   .:||.||:|.|..:
Human   130 NIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQI 194

  Fly   298 SPKCLIQLA-ALSHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLEL------TDFMNVIQL-G 354
            :...:..|. ....|:.|...|..:.  ::|....:.:||..|..|.|      || ..|:|: .
Human   195 TKDGIEALVRGCRGLKALLLRGCTQL--EDEALKHIQNYCHELVSLNLQSCSRITD-EGVVQICR 256

  Fly   355 GLSRLHTLVIHSSAQLDYHVNNVLLTSIAESYSLRHLEILDS--FGPMSDTSFDLSIFSQLKELR 417
            |..||..|.:...:.|    .:..||::  ..:...|:||::  ...::|..|.| :.....||.
Human   257 GCHRLQALCLSGCSNL----TDASLTAL--GLNCPRLQILEAARCSHLTDAGFTL-LARNCHELE 314

  Fly   418 TLILHNQNFTT--------LHLMGLQKLSTLEFLD-------------------------LSGSP 449
            .:.|......|        :|...||.|.:|.|.|                         ||...
Human   315 KMDLEECILITDSTLIQLSIHCPKLQALVSLSFSDIIHLLKMKEPSHHNKKLFGFSFCKSLSHCE 379

  Fly   450 NLSNEVVAKLTKSLSG---LRRLKVDFCPLITRQLTKILE 486
            .::::.:..|:.|..|   ||.|::|.|.|||....:.||
Human   380 LITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLE 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14891	NP_650560.1	RRM	41..92	CDD:214636
		leucine-rich repeat	211..237	CDD:275381
		LRR	<235..>463	CDD:443914	65/272 (24%)
		leucine-rich repeat	239..262	CDD:275381	6/24 (25%)
		leucine-rich repeat	263..285	CDD:275381	9/24 (38%)
		leucine-rich repeat	286..338	CDD:275381	13/52 (25%)
		leucine-rich repeat	339..387	CDD:275381	14/54 (26%)
		leucine-rich repeat	388..415	CDD:275381	6/28 (21%)
		leucine-rich repeat	416..439	CDD:275381	7/30 (23%)
		leucine-rich repeat	440..465	CDD:275381	7/49 (14%)
FBXL2	XP_054201991.1	F-box_FBXL2-like	34..78	CDD:438887
		leucine-rich repeat	77..104	CDD:275381
		AMN1	<101..248	CDD:187754	34/119 (29%)
		leucine-rich repeat	105..124	CDD:275381
		leucine-rich repeat	131..156	CDD:275381	6/24 (25%)
		leucine-rich repeat	157..182	CDD:275381	9/24 (38%)
		leucine-rich repeat	183..208	CDD:275381	7/24 (29%)
		AMN1	193..423	CDD:187754	52/236 (22%)
		leucine-rich repeat	209..234	CDD:275381	6/26 (23%)
		leucine-rich repeat	235..260	CDD:275381	8/25 (32%)
		leucine-rich repeat	261..286	CDD:275381	5/30 (17%)
		leucine-rich repeat	287..312	CDD:275381	6/25 (24%)
		leucine-rich repeat	313..338	CDD:275381	4/24 (17%)
		leucine-rich repeat	339..389	CDD:275381	8/49 (16%)
		leucine-rich repeat	399..418	CDD:275381	8/18 (44%)