DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Decay and CFLAR

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001120655.1	Gene:	CFLAR / 8837	HGNCID:	1876	Length:	480	Species:	Homo sapiens

Alignment Length:	294	Identity:	72/294 - (24%)
Similarity:	117/294 - (39%)	Gaps:	50/294 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DFSLFGQKNKHKKDKADATKIAHTPTSELDLKRIIISRPTNEDTYENCAR-AGIALILNHKDVKG 68
            :|.|...::|.::.|.............:......:.:...|:.|:..:: .||.||:   |..|
Human   200 NFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLII---DCIG 261

  Fly    69 QKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVA-REDHSQNDCFVLAVMSHGTE 132
            .:    ||..||    |....|::|:.|..|:...|:..|.:.| ..:|...|.||..::|.|..
Human   262 NE----TELLRD----TFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGS 318

  Fly   133 GKVYAKDMSY---PVERLWNPFLGDNCKTLKNKPKLFFIQACRGANL---EKAVEFSSFAVMTRE 191
            ..||..|.::   |:..:...|:||:|..|..|||:||||     |.   |..:|.||
Human   319 QSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQ-----NYVVSEGQLEDSS------- 371

  Fly   192 LVPEPAAAVQPITY--------AIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAA 248
            |:.....|::.:.:        .:...||......|.|.....::....|.::|.|.:.|.|
Human   372 LLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ--- 433

  Fly   249 NEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEA 282
             |...|    ||.|...:|   .|.|..|::..|
Human   434 -ERKRP----LLDLHIELN---GYMYDWNSRVSA 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	66/245 (27%)
CFLAR	NP_001120655.1	Not proteolytically processed and involved in apoptosis inhibition	1..435		62/261 (24%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..305		25/115 (22%)
		Interaction with FADD. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..227		4/26 (15%)
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..195
		DED_c-FLIP_r1	1..80	CDD:260044
		DED_c-FLIP_r2	91..171	CDD:260046
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269\|PubMed:9208847	192..480		72/294 (24%)
		Interaction with CASP3. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	192..435		62/261 (24%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	217..480		68/277 (25%)
		CASc	244..479	CDD:214521	67/250 (27%)
		Caspase	263..358		32/102 (31%)
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	370..480		23/108 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740