DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and CASP10

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_116759.2	Gene:	CASP10 / 843	HGNCID:	1500	Length:	522	Species:	Homo sapiens

Alignment Length:	276	Identity:	89/276 - (32%)
Similarity:	135/276 - (48%)	Gaps:	30/276 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AHTPTSELDLKRIIISRPTNEDTYENCARAGIALILNHKDVKGQKQRVGTERDRDDMEATLQGFG 90
            |:|..||...||..:.|       .|....|:.:|:|:......|.|.||.:|.:.:....|..|
Human   261 ANTLNSETSTKRAAVYR-------MNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLG 318

  Fly    91 FDVRTFDDLTFSEINDTL-KEVAREDHSQNDCFVLAVMSHGTEGKVYAKDMS-YPVERLWNPFLG 153
            |.|...:::|..|:...| |:.....|:..||||..:::||..|.||:.|.: .|:..:.:.|..
Human   319 FTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTA 383

  Fly   154 DNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVPEPAAAVQPITYAIPSTADILVFYS 218
            ..|..|..||||||||||:|..::.:|...:.|:       .|..|...:..:||:.||.|:..:
Human   384 LQCPRLAEKPKLFFIQACQGEEIQPSVSIEADAL-------NPEQAPTSLQDSIPAEADFLLGLA 441

  Fly   219 TFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEY-QSNTKNEA 282
            |...:.|||:|::|||:|||||..|      :...|...::|.:|||||..|:... :..||
Human   442 TVPGYVSFRHVEEGSWYIQSLCNHL------KKLVPRHEDILSILTAVNDDVSRRVDKQGTK--- 497

  Fly   283 LNQMKEMPNFMSTLTK 298
                |:||....||.|
Human   498 ----KQMPQPAFTLRK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	81/248 (33%)
CASP10	NP_116759.2	DD	18..99	CDD:326335
		DED_Caspase_10_r2	112..190	CDD:260074
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..269		4/7 (57%)
		CASc	276..514	CDD:214521	83/261 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770