DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and CASP9

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	XP_011540575.1	Gene:	CASP9 / 842	HGNCID:	1511	Length:	421	Species:	Homo sapiens

Alignment Length:	258	Identity:	79/258 - (30%)
Similarity:	120/258 - (46%)	Gaps:	43/258 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DLKRIIISRPTNEDTYENCARAGIALILNHKDV---KGQKQRVGTERDRDDMEATLQGFGFDVRT 95
            ||..|:...|           .|..||:|:.:.   .|.:.|.|:..|.:.:........|.|..
Human   150 DLAYILSMEP-----------CGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEV 203

  Fly    96 FDDLTFSEINDTLKEVAREDHSQNDCFVLAVMSHGTE-------GKVYAKD-MSYPVERLWNPFL 152
            ..|||..::...|.|:|::||...||.|:.::|||.:       |.||..| ....||::.|.|.
Human   204 KGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFN 268

  Fly   153 GDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRE--LVPEPAAA-----------VQPIT 204
            |.:|.:|..||||||||||.|...:...|.:|.:.....  ..|||.|.           :..|:
Human   269 GTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAIS 333

  Fly   205 YAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVN 267
             ::|:.:||.|.||||..|.|:|:...|||::::|..:.:|.|.:|       :|..||..|:
Human   334 -SLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE-------DLQSLLLRVS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	75/238 (32%)
CASP9	XP_011540575.1	CARD_CASP9	17..90	CDD:176740
CASP9	XP_011540575.1	CASc	152..397	CDD:237997	77/256 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700