DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and CASP5

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001129584.1	Gene:	CASP5 / 838	HGNCID:	1506	Length:	447	Species:	Homo sapiens

Alignment Length:	314	Identity:	77/314 - (24%)
Similarity:	126/314 - (40%)	Gaps:	67/314 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DKADATKIAHTPTSELDLKRIIISRPTNEDTY---ENCARAGIALILNHKDVKGQKQRVGTERDR 79
            :.|::|.|......|..|:   :.:..:::.|   :...|..:|||:.:........|.|...|.
Human   168 ESAESTNILKLCPREEFLR---LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDI 229

  Fly    80 DDMEATLQGFGFDVRTFDDLTFSEINDTLKE-VAREDHSQNDCFVLAVMSH-------GTEGKVY 136
            ..|:..|||.|:.|....:||..::...|:. .||.:|..:|...|.:|||       ||..|..
Human   230 VGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKK 294

  Fly   137 AKDMSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEF------SSFAVMTRELVPE 195
            ..|:.. .:.::..|...||.:||:|||:..:|||||   ||..|.      :|.|:::.:....
Human   295 KPDVLL-YDTIFQIFNNRNCLSLKDKPKVIIVQACRG---EKHGELWVRDSPASLALISSQSSEN 355

  Fly   196 PAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSL----------CRVLDQAAANE 250
            ..|   .....|....|.:.|.|:.....|:|:...||.||..|          |.:::
Human   356 LEA---DSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME------ 411

  Fly   251 AATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMK-EMPNF-MSTLTKTFQL 302
                           :.|||...::       :.|.| :||.. .:|||:.|.|
Human   412 ---------------IFRKVQKSFE-------VPQAKAQMPTIERATLTRDFYL 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	70/273 (26%)
CASP5	NP_001129584.1	DD	76..155	CDD:301326
CASP5	NP_001129584.1	CASc	196..445	CDD:214521	72/283 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740