DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and CASP4

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001216.1	Gene:	CASP4 / 837	HGNCID:	1505	Length:	377	Species:	Homo sapiens

Alignment Length:	246	Identity:	69/246 - (28%)
Similarity:	104/246 - (42%)	Gaps:	44/246 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DKADATKIAHTPTSELDLKRIIISRPTNEDTY---ENCARAGIALILNHKDVKGQKQRVGTERDR 79
            :..||.|:.  |..|.    :.:.:...|:.|   |...|..:|||:.:.:......|.|.:.|.
Human   101 ESTDALKLC--PHEEF----LRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDI 159

  Fly    80 DDMEATLQGFGFDVRTFDDLTFSEINDTLKEVA-REDHSQNDCFVLAVMSHGTE----GKVYAKD 139
            ..|:..|:|..:.|...::||..::...|:..| |.:|..:|...|.:||||..    |.|:  |
Human   160 TGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVH--D 222

  Fly   140 MSYP----VERLWNPFLGDNCKTLKNKPKLFFIQACRGAN------------LEKAVEFSSFAVM 188
            ...|    .:.::..|...||.:||:|||:..:|||||||            ||.|...||
Human   223 EKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSS---- 283

  Fly   189 TRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSL 239
              |.:.|.|      .|......|.:.|.|:.....|:|:...||.||..|
Human   284 --ENLEEDA------VYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	61/207 (29%)
CASP4	NP_001216.1	Required for LPS-binding. /evidence=ECO:0000250\|UniProtKB:P70343	1..59
		CARD_CASP1-like	5..81	CDD:260036
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..104		0/2 (0%)
		CASc	126..375	CDD:214521	63/215 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740