Protein Alignment Decay and Casp8

DIOPT Version :10

• Sequence 1: NP_477462.1
• Gene: Decay / 42008
• FlyBaseID: FBgn0028381
• Length: 308
• Species: Drosophila melanogaster
• Sequence 2: NP_071613.1
• Gene: Casp8 / 64044
• RGDID: 620945
• Length: 482
• Species: Rattus norvegicus
• Alignment Length: 322
• Identity: 95/322 - (29%)
• Similarity: 149/322 - (46%)
• Gaps: 46/322 - (14%)

  Fly     7 SLFGQKNKHKKDKADATKIA----HTPTSELDLKRIII-----------SRPTNED-TYENCAR- 54
            ||.|:.:.:::...:.....    ..|.|.||...|.:           |...|.| .|:..::
  Rat   170 SLLGRIDDYERSSTERRMSTEGGEELPVSVLDEVTIKMQDMWDSPGEQESESLNSDNVYQMKSKP 234

  Fly    55 AGIALILNHKD----------VKGQKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLK 109
            .|..||.|:.:          :...:.|.||..|.:.:..|.:...|::.:|.|.|.|:|::.|.
  Rat   235 RGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTFKELHFEIVSFSDCTASQIHEVLV 299

  Fly   110 EVAREDHSQNDCFVLAVMSHGTEGKVYAKD-MSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRG 173
            ....:||...|||:..::|||.:|.||..| ....:..|.:.|.|..|.:|..|||:||||||:|
  Rat   300 SYQSKDHKGKDCFICCILSHGDKGIVYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQACQG 364

  Fly   174 ANLEKAVEFSSFAVMTRELVPEPAAAVQPITYA--IPSTADILVFYSTFDKFFSFRNVDDGSWFI 236
            .|.:|||.......:.:|.|.|..::    :|.  ||..||.|:..:|.....|:|:...|:|:|
  Rat   365 NNFQKAVPVPDETGLEQEHVLEEDSS----SYKNYIPDEADFLLGMATVKNCVSYRDPTRGTWYI 425

  Fly   237 QSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTK 298
            ||||:.|.:..      |.|.::|.:||.||      |..:.|:...|..|:||..:.||.|
  Rat   426 QSLCQSLRERC------PRGEDILSILTGVN------YDVSNKDNPRNMGKQMPQPIFTLRK 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	83/259 (32%)
Casp8	NP_071613.1	DED_Caspase_8_r1	3..84	CDD:260041
		DD	98..179	CDD:472698	3/8 (38%)
		CASc	227..480	CDD:237997	84/265 (32%)