DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and casp8

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	XP_005165894.1	Gene:	casp8 / 58022	ZFINID:	ZDB-GENE-000713-1	Length:	477	Species:	Danio rerio

Alignment Length:	304	Identity:	90/304 - (29%)
Similarity:	139/304 - (45%)	Gaps:	43/304 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QKNKHKKDKADATKIAHTPTSELDLKRIIISRPTNEDTYENCARAGIALILNHKD-VKGQK--QR 72
            ::.:........|..|.||.:..:. .|:..||           .|..||:|:.: :|...  :|
Zfish   206 RERRRNSSAGTITTDAETPLNPNEY-YILTQRP-----------LGYCLIINNYNFLKSTNLLKR 258

  Fly    73 VGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAREDHSQNDCFVLAVMSHGTEGKVYA 137
            .||:.|:|.:........|.:....||....|.|.:|:.|.::|:....||..::|||.:|.|..
Zfish   259 TGTDMDKDRLAKLFSRMHFQIEVRSDLEAWAIKDEIKQFANKNHASMGAFVCCILSHGEKGTVLG 323

  Fly   138 KDMSYPVE--RLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVPEPAAAV 200
            .| ..|||  .:..||.|  |:||.:||||||||||:|...:..|..|.    .||..||.....
Zfish   324 TD-GKPVEIREVTLPFAG--CRTLASKPKLFFIQACQGDENQAGVWTSD----GREDAPEEDEKY 381

  Fly   201 QP-----ITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELL 260
            :.     :...||..||.|:..:|.:.:.|:|:..:||.|||.||:.:::..      |:..::|
Zfish   382 EEDAGIIVLRKIPIEADFLIGMATVEHYLSYRHTKEGSIFIQELCKKMEELC------PKKEDML 440

  Fly   261 RLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTKTFQLRV 304
            .:||.||.:|:        ...|...|:||....||||...|.:
Zfish   441 SILTKVNFEVS--------KRILKGYKQMPEPRYTLTKKLVLPI 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	82/257 (32%)
casp8	XP_005165894.1	DED_Caspase_8_10_r1	2..76	CDD:260059
		DED_Caspase_8_10_r2	96..176	CDD:260042
		CASc	230..475	CDD:237997	85/277 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740