DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and Casp1

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_036894.3	Gene:	Casp1 / 25166	RGDID:	2274	Length:	402	Species:	Rattus norvegicus

Alignment Length:	300	Identity:	78/300 - (26%)
Similarity:	127/300 - (42%)	Gaps:	59/300 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KKDKADATKIAHTPTSELDLKRIIISRPTNEDTYENCARAGIALILNHKDVKGQKQRVGTERDRD 80
            |::.::...|..|||                       |..:|||:.:.|.:...:|||.:.|..
  Rat   145 KENHSEIYPIMKTPT-----------------------RTRLALIICNTDFQHLSRRVGADVDLR 186

  Fly    81 DMEATLQGFGFDVRTFDDLTFSEINDTLKEVAR-EDHSQNDCFVLAVMSHGTE----GKVYAKDM 140
            :|:..||..|:.|:..::||..|:...|||.|. .:|..:|...|..||||.:    |..|:.::
  Rat   187 EMKLLLQDLGYTVKVKENLTALEMTKELKEFAACPEHKTSDSTFLVFMSHGLQEGICGITYSNEV 251

  Fly   141 S--YPVERLWNPFLGDNCKTLKNKPKLFFIQACRGAN-----LEKAVEFSSFAVMTRELVPEPAA 198
            :  ..|:.::.......|.:||:|||:..||||||..     |:.:|..|....:|..:..:...
  Rat   252 ADILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVGNSEEGFLTDAIFEDDGI 316

  Fly   199 AVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLL 263
            ....|      ..|.:.|.|:.....|:|:...||.||:||.:.:.:.|.:..           |
  Rat   317 KKAHI------EKDFIAFCSSTPDNVSWRHPVQGSLFIESLIKHMKEYAWSCD-----------L 364

  Fly   264 TAVNRKVAYEYQSNTKNEALNQMKEMPNF-MSTLTKTFQL 302
            ..:.|||.:.:      |..:...:||.. ..||||.|.|
  Rat   365 EDIFRKVRFSF------EQPDSRLQMPTTERVTLTKRFYL 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	72/260 (28%)
Casp1	NP_036894.3	CARD_CASP1-like	6..87	CDD:260036
Casp1	NP_036894.3	CASc	152..400	CDD:214521	76/292 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740